Wan X

BackgroundInfertility poses a significant health challenge for reproductive-aged women globally and could be shaped by both genetic risks and lifestyle factors. Existing studies predominantly focus on individual lifestyle components, while …

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, is closely associated with mitochondrial damage, diminished glutathione peroxidase 4 activity, dysfunction of the System Xc- cystine/glutamate antipor…

BackgroundOverweight and obesity are link to impaired endometrial receptivity and decreased pregnancy success in frozen-thawed embryo transfer (FET) cycles. Depot gonadotropin-releasing hormone agonist (GnRH-a) pretreatment before hormone r…

BackgroundKuntai capsules, a traditional Chinese medicine, are speculated to improve the treatment outcomes of patients with ovarian reserve dysfunction (DOR), but existing evidence is limited.ObjectiveTo investigate the effects of Kuntai c…

BACKGROUND: Acute pancreatitis (AP) can be mild and self-limited, but it can also become severe acute pancreatitis (SAP) and lead to multi-organ dysfunction. It is still difficult to identify patients who may develop severe disease at an ea…

PURPOSE: This study aimed to develop a joint model combining T2-weighted imaging (T2WI) suppressed fat radiomics, and clinical parameters to predict the energy efficiency factor (EEF) required for high-intensity focused ultrasound (HIFU) ab…

BACKGROUND: Fresh embryo transfer reduces waiting time and minimizes embryo cryodamage for endometriosis (EM) patients. The current prediction models for fresh embryo transfer outcomes in EM primarily rely on logistic regression, with limit…

AIMS: To develop a model predicting high-intensity focused ultrasound (HIFU) efficacy in adenomyosis treatment using enhanced T1WI and T2WI-FS radiomics combined with clinical imaging features. MATERIALS AND METHODS: The study included 137…

OBJECTIVES: The study aimed to develop a non-enhanced MRI-based radiomics model for the preoperative prediction of the efficacy of adenomyosis after high-intensity focused ultrasound (HIFU) treatment. METHODS: The data of 130 patients with…

OBJECTIVE: To determine the clinical and embryo laboratory factors that affect the clinical pregnancy rate of infertile patients with endometriosis (EMs), and establish a model for predicting clinical pregnancy. STUDY DESIGN: An observatio…

BACKGROUND: Previous studies on the impact of mitochondrial DNA (mtDNA) copy number on female infertility were limited and inconsistent. METHODS: The causal relationship between mtDNA copy number and female infertility was evaluated using …

Gallbladder carcinoma (GBC) is a malignant tumor of the biliary system that is aggressive, difficult to detect early, and has a low surgical resection rate and poor prognosis. Appropriate in vitro growth models are expected to focus on the …

Objective Analyze the differences in the laboratory indexes and baseline clinical characteristics between the endometriosis(EMs) patients with or without combination of endometrial polyps(EPs), and establish an efficient combined prediction…

In vitro fertilization-embryo transfer (IVF-ET), a well-developed technology, provides the last possibility or hope for infertile women. However, the live birth rate per IVF cycle is still not satisfactory. Acupuncture is a frequently used …

BackgroundIntrauterine adhesion (IUA) is one of the most important causes of female infertility, while iatrogenic endometrial injury is the main, but not the entire, cause of IUA. The microorganisms of the female reproductive tract play an …

ObjectiveThe aim of this study was to examine the effect of TRIB3 on proliferation, apoptosis, and migration of endometrial cancer (EC) cells and explore the relationship between TRIB3 and AKT signaling pathway in EC progression.MethodsImmu…

Ovarian fibroma/fibrothecoma with elevated serum OC125 antigen (CA125) is rarely encountered in clinical practice, and also easily misdiagnosed as epithelial ovarian carcinoma (EOC). The aim of this study was to investigate the clinicopatho…

BACKGROUND: Given the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the devel…

BackgroundThe Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable compariso…

Endometriosis is a prevalent and complex gynecological disease which affects 10% of women of reproductive age. Certain studies have suggested that a substantial number of microRNAs (miRNAs or miRs) are aberrantly or differentially expressed…

Recent data support a role for SHARP1, a basic helix-loop-helix transcription repressor, in the regulation of malignant cell behavior in several human cancers. However, the expression and role of SHARP1 during the development of endometrial…

Infection by human papillomavirus (HPV) can cause cervical intraepithelial neoplasia (CIN) and cancer. Down-regulation of E6 and E7 expression may be responsible for the positive clinical outcomes observed with IFN treatment, but the molecu…

BackgroundChina has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health …

Mechanisms governing the metastasis of endometrial carcinoma (EC) are poorly defined. Recent data support a role for the cell surface receptor tyrosine kinase TrkB in the progression of several human tumors. Here we present evidence for a d…