Idhaliz Flores

Endometriosis is a gynecological disease that affects 1 in 10 women during their reproductive years, cause incapacitating pelvic pain and infertility. Endometriosis is characterized by the growth of endometrial tissue outside the uterine ca…

Abstract Endometriosis, a common painful and inflammatory gynecological disease, has been proposed to contribute to the development of endometriosis-associated ovarian cancer, specifically the endometrioid and clear cell subtypes. The mecha…

OBJECTIVE: To quantify the impact of endometriosis-related symptoms on physical and mental health status, health-related quality of life, and work-related aspects (absenteeism, presenteeism, work productivity, and activity impairment). DES…

This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like pr…

Population-based studies are important to address emerging issues in health disparities among populations. The Partnership between the Moffitt Cancer Center (MCC) in Florida and the Ponce School of Medicine and Health Sciences (PSMHS) in Pu…

Endometriosis is considered a multifactorial disease influenced by genetic predisposition, deficient immune system and environmental factors. The most common symptoms are chronic pelvic pain and infertility. The pathophysiological mechanism…

Endometriosis is associated with activation of local and systemic inflammatory mechanisms, including increased levels of chemokines and other proinflammatory cytokines. We have previously reported increased gene expression of chemokine rece…

Endometriosis is a gynecological disease characterized by the presence of stroma and epithelial cells outside the uterine cavity, causing pain and infertility. This disease is estrogen-dependent and is associated with the activation of infl…

The objective of this study was to assess the burden of endometriosis by obtaining patient-reported outcome data describing the experience of living with this disease. Survey data from 107 women with self-reported, surgically diagnosed endo…

It is not known whether stress affects the severity of endometriosis in women. Aim: Assess the effects of chronic stress in an established animal model of intestinal endometriosis. Methods: Endometriosis was surgically induced in female rat…

Endometriosis commonly presents with symptoms that mimic chronic gastrointestinal disorders. The authors used the autotransplantion model of endometriosis in rats to investigate the possible underlying mechanisms. After the rats were killed…

OBJECTIVE: To validate a rat model of endometriosis using complimentary DNA (cDNA) microarrays by identifying common gene expression patterns between experimental and natural disease. DESIGN: Autotransplantation rat model. SETTING: Medica…

OBJECTIVE: To determine the prevalence of endometriosis and its symptoms in a Puerto Rican cohort, and to describe the menstrual, obstetric, and clinical profiles of the women. METHODS: A self-administered questionnaire was given to 1285 P…

Endometriosis is a common, incurable gynecologic disease of unknown etiology, which causes incapacitating pain during menses and infertility. There are no specific non-invasive diagnostic tests for endometriosis, therefore diagnosis is curr…

OBJECTIVE: To identify molecular biomarkers for endometriosis in peripheral blood lymphocytes by using DNA microarrays. DESIGN: Case-control. SETTING: Multicenter academic research programs. PATIENT(S): Premenopausal women with or withou…

Endometriosis is commonly associated with symptoms similar to those of gastrointestinal diseases, such as inflammatory bowel disease (IBD), leading to erroneous diagnosis and inappropriate management. The role of tumor necrosis factor alpha…

Objective: To establish the prevalence of endometriosis in Puerto Rico, which has not been previously studied. Design: A cross-sectional study was conducted by applying a self-administered questionnaire to 398 women aged 18 to 55 from south…