Thomas D’Hooghe

No ORCID on file · 255 papers in corpus · active 1991-2026

Study types

  • article 181
  • review 35
  • letter 11
  • book-chapter 8
  • other 6

Condition tags

  • endometriosis 229
  • infertility 37
  • dysmenorrhea 9
  • chronic_pelvic_pain 8
  • dyspareunia 6
  • adenomyosis 3
  • endometrioma 2
  • die_deep_infiltrating 2
  • disambig:endometritis 1
  • bowel_endometriosis 1
article 2009
Combined proteomic and RNA microarray analysis after TRIzol extraction of eutopic endometrium for endometriosis biomarker discovery
·doi:10.1016/j.fertnstert.2009.07.1104
article 2009
Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis
Human Reproduction ·doi:10.1093/humrep/dep283

BACKGROUND: The aim of our study was to test the hypothesis that multiple-sensory small-diameter nerve fibres are present in a higher density in endometrium from patients with endometriosis when compared with women with a normal pelvis, ena…

article 2009
Endometriosis and autoimmune disease: association of susceptibility with PTPN22
·doi:10.1016/j.fertnstert.2009.07.040
article 2009
Increased Production of 17β-Estradiol in Endometriosis Lesions is The Result of Impaired Metabolism
Molecular Endocrinology ·doi:10.1210/mend.23.2.9993

Context: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17β-estradiol. However, whether these differences result in a net incre…

review 2009
Nonhuman Primate Models for Translational Research in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719108322430

Endometriosis, defined as the ectopic presence of endometrial-like cells, is associated with infertility and pelvic pain in women. Whereas pathogenesis and spontaneous evolution of endometriosis are still poorly understood, recurrences afte…

article 2009
Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers
Human Reproduction ·doi:10.1093/humrep/dep425

BACKGROUND: Lack of a non-invasive diagnostic test contributes to the long delay between onset of symptoms and diagnosis of endometriosis. The aim of this study was to evaluate the combined performance of six potential plasma biomarkers in …

article 2009
Outcome after multidisciplinary CO2 laser laparoscopic excision of deep infiltrating colorectal endometriosis
Reproductive biomedicine online ·doi:10.1016/s1472-6483(10)60267-2

The aim of this retrospective cohort study was to evaluate clinical outcome after multidisciplinary laparoscopic excision of deep endometriosis. Patients (n = 56) were asked to complete questionnaires regarding quality of life (QOL), pain, …

article 2009
Quantity and quality of retrograde menstruation: a case control study
Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-7-123

BACKGROUND: The purpose of this study was to test the hypothesis that menstruation is associated with a higher concentration of endometrial cells in peritoneal fluid(PF) and with increased white and red blood cell concentration in PF when c…

article 2009
Reply of the Authors: Endometriosis: is laparoscopy justified without previous ultrasonogram and magnetic resonance imaging (MRI)? & High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners
·doi:10.1016/j.fertnstert.2009.11.028
article 2009
The effect of JNK-inhibitors on endometriosis in baboons with induced disease: a placebo-controlled randomized study
·doi:10.1016/j.fertnstert.2009.07.044
article 2009
The role of the Fallopian tube in the development of endometriosis
article 2008
Endometrial multiple small sensory nerve fibers in minimal and mild endometriosis
·doi:10.1016/j.fertnstert.2008.07.636
article 2008
Ethical acceptability of research on nonhuman primates in the field of infertility and endometriosis: the patient perspective
article 2008
Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis
Human Reproduction ·doi:10.1093/humrep/den078

BACKGROUND: Endometriosis occurs in 10% of women and is currently diagnosed by invasive laparoscopic testing. We tested the hypothesis that endometrial gene expression in late secretory phase endometrium differs between patients with and wi…

article 2008
Health economics of endometriosis
article 2008
High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.04.056

ObjectiveTo determine the prevalence of histologically proven endometriosis in a subset of infertile women.DesignRetrospective case series with electronic file search and multivariable logistic regression analysis.SettingTertiary academic f…

article 2008
Increased Production of 17β-Estradiol in Endometriosis Lesions Is the Result of Impaired Metabolism
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2008-2218

CONTEXT: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17beta-estradiol. However, whether these differences result in a net in…

article 2008
Proteomics in translational research: an integrated approach in the pathogenesis and diagnosis of endometriosis
article 2008
The patient with endometriosis: achieving pregnancy
·doi:10.3109/9780203092200.021
article 2007
Baboon Model for the Study of Endometriosis
Women's health (London, England) ·doi:10.2217/17455057.3.5.637

Endometriosis is a benign, estrogen-dependent disease and is now recognized as an enigmatic disease owing to its various clinical manifestations and locations. The lack of a reliable and specific method for the early detection of endometrio…

article 2007
Effect of recombinant human TNF–binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.11.205

ObjectiveTo evaluate the mechanism of action of recombinant human tumor necrosis factor (TNF)-binding protein-1 by assessing differential expression of messenger RNA (mRNA) for cytokines, matrix metalloproteinases, and growth and adhesion f…

article 2007
Effects of anti-TNF-mAb treatment on pregnancy in baboons with induced endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.05.062

ObjectiveHormonal suppressive therapy is not effective for endometriosis-associated subfertility and can even prevent conception. Medical inhibition of TNFalpha, which has been shown to improve conception, is effective in the prevention and…

article 2007
Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.02.057

ObjectiveTo examine messenger (m) RNA expression of aromatase, cytokines, and adhesion factors in women with and without endometriosis.DesignPatients with endometriosis were compared with control patients.SettingUniversity Hospital Gasthuis…

article 2007
Endometrial biomarkers for semi-invasive diagnosis of endometriosis
review 2007
Endometriosis and Genetic Polymorphisms
Obstetrical & gynecological survey ·doi:10.1097/01.ogx.0000279293.60436.60

UNLABELLED: Endometriosis is a benign gynecological disease with an unclear pathophysiology characterized by ectopic endometrium causing endometrium-like inflammatory lesions outside the uterine cavity. Recently, a number of studies have in…