Chen Chen

ORCID: 0000-0001-9159-4489 · 14 papers in corpus · active 2004-2025

Study types

  • other 6
  • article 3
  • review 2

Condition tags

  • endometriosis 7
  • adenomyosis 3
  • dysmenorrhea 2
  • infertility 1
  • die_deep_infiltrating 1
other 2025
Nature communications ·doi:10.1038/s41467-025-57173-2

Over 75% of failed pregnancies involve implantation defects. Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein involved in signal transduction and cell communication. Here we show that the expression of GRB2 protein is low…

other 2025
Scientific reports ·doi:10.1038/s41598-025-22880-9

Levonorgestrel intrauterine-releasing system (LNG-IUS), an intrauterine device, is recommended for patients with adenomyosis; however, it often shows poor outcomes in these patients because of their large uterine size. This prospective stud…

review 2025
Phytomedicine : international journal of phytotherapy and phytopharmacology ·doi:10.1016/j.phymed.2025.157353

BACKGROUND: Angiogenesis is a key link in a variety of physiological and pathological processes and plays a crucial role in tissue repair, tumor growth and ischemic diseases. Ginsenosides, as the main active component of ginseng, have a uni…

article 2024
Journal of biological engineering ·doi:10.1186/s13036-024-00466-9

This study addresses the challenges in the early diagnosis of deep infiltrating endometriosis (DIE) by exploring the potential role of the deubiquitinating enzyme USP14. By analyzing the GSE141549 dataset from the Gene Expression Omnibus (G…

2023
·doi:10.20944/preprints202311.1787.v1
2021
·doi:10.21203/rs.3.rs-303016/v1
article 2019

Tested steels are melting by a 50 kg medium induction furnace and rolling to 13 mm plate. The effect of rolling temperature (1 010 ~ 1 050 ℃) of tested steel 0.15Mo,R2- 0.15MoV, R3- 0.35MoNbV, R4- 0.35MoNbVB and R5- 0.35MoNbVTiB on properti…

2019
·doi:10.21203/rs.2.16837/v1
other 2017
Nature communications ·doi:10.1038/s41467-017-00901-0

Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of de…

other 2014
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.10.050

OBJECTIVE: To investigate the balance between regulatory T cells (Treg) and T-helper 17 cells (T(H)17) in peripheral blood and uteri of women with adenomyosis (AM), and to evaluate their potential correlation with dysmenorrhea and CA-125 le…

article 2009
·doi:10.1093/biolreprod/81.s1.364

Polycystic ovary syndrome (PCOS) is characterized by excessive theca cell androgen secretion, dependent upon LH, which acts through the intermediacy of adenosine 3', 5'-cyclic monophosphate (cAMP). cAMP signaling pathways are controlled thr…

other 2008
Journal of medicinal chemistry ·doi:10.1021/jm8006454

The discovery of novel uracil phenylethylamines bearing a butyric acid as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonists is described. A major focus of this optimization was to improve the CYP3A4 inhibition liabi…

other 2007
Endocrinology ·doi:10.1210/en.2006-1213

Suppression of the hypothalamic-pituitary-gonadal axis by peptides that act at the GnRH receptor has found widespread use in clinical practice for the management of sex-steroid-dependent diseases (such as prostate cancer and endometriosis) …

review 2004
Current opinion in drug discovery & development

Recent success in the search for orally active gonadotropin-releasing hormone antagonists for the treatment of sex hormone-related diseases, such as endometriosis, uterine fibroids and prostate cancer, has resulted in the discovery of non-p…