Chen Y

BackgroundPrimary dysmenorrhea (PDM), as a form of chronic pelvic pain, has a complex pathophysiology involving hormonal factors, central nervous system alterations, and maladaptive pain cognition. Previous neuroimaging studies have demonst…

Background: Polycystic ovary syndrome (PCOS) is characterized by substantial inter-individual variability in ovarian sensitivity to recombinant follicle-stimulating hormone (rFSH) during controlled ovarian stimulation (COS). Clinically appl…

BACKGROUND: Assisted reproductive treatment for women with endometriosis and diminished ovarian reserve (DOR) is challenging, and the optimal controlled ovarian stimulation (COS) protocol for this population remains uncertain. This study co…

BACKGROUND: Recent studies have disputed the association between bisphenol A (BPA) and endometriosis. This updated meta-analysis was conducted to investigate the impact of BPA exposure on endometriosis. METHODS: This study evaluated BPA ex…

OBJECTIVE: Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to explore the associ…

BackgroundPreeclampsia (PE) is a significant complication of pregnancy, and its association with in vitro fertilization (IVF) remains unclear, especially across different demographic groups.MethodsWe conducted a retrospective multicenter co…

BackgroundIn mammals, precise regulation of primordial follicle activation is essential for maintaining the female reproductive lifespan. In this study, we demonstrated that the vitamin D receptor (VDR) is expressed in both pre-granulosa ce…

BackgroundPelvic floor dysfunction (PFD) is a common cause of chronic constipation which can reciprocally exacerbate pelvic floor burden. However, the characteristics and evolution of pelvic floor structures in patients with constipation re…

BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with both reproductive and metabolic dysregulation. While anti-Müllerian hormone (AMH) and the triglyceride-glucose (TyG) index have been independen…

BackgroundThe relationship between preimplantation hematological profiles and clinical pregnancy rates following frozen embryo transfer (FET) has not been thoroughly investigated.MethodsA retrospective study was conducted. Participants were…

BackgroundLow birth weight (LBW) significantly influences neonatal prognosis as well as growth and development in adult. This study aimed to explore the increased risk of low birth weight (LBW) in singleton live births in connection with in…

OBJECTIVE: To investigate the therapeutic effects and mechanisms of curcumin (Cur) in adenomyosis (AM). METHODS: A mouse uterine AM model was established by exposing ICR neonatal mice to tamoxifen (TAM). Female neonatal mice (day 1, n=24) …

Endometriosis is a complex gynecological disorder with prominent cellular heterogeneity, and its key pathogenic cell subsets and core molecular mechanisms remain elusive, which restricts the development of effective therapeutic strategies. …

Background/Objectives: Primary dysmenorrhea is a common gynecological disorder characterized by painful uterine contractions. Danggui Buxue Decoction (DBD) is used to treat menstrual irregularities, but its mechanism in primary dysmenorrhea…

BACKGROUND: The clinical association between female reproductive disorders, such as endometriosis, polycystic ovary syndrome(PCOS), uterine leiomyoma, and female infertility and psychiatric disorders, such as major depressive disorder(MDD),…

PURPOSE: This paper provides a systematic review of the current applications of diffusion tensor imaging (DTI) in the imaging of pelvic floor-related anatomical structures and the assessment of microscopic pathological changes. METHODS: A …

BACKGROUND: Early-life exposures may influence long-term reproductive health, but comprehensive population-based evidence remains limited. This study aimed to evaluate the associations between six early-life factors (long-term/recurrent ant…

OBJECTIVE: To evaluate the efficacy of intraoperative adhesion barriers in reducing long-term recurrence and alleviating pelvic pain in patients with endometriosis following laparoscopic surgery. METHODS: A retrospective analysis was perfo…

Yao Hu,1,* Yan Chen,1,* Gaolian Li,1 Qingjing Zou,1 Jiawei Zhan,2 Dongmei Li3 1Department of Obstetrics and Gynecology, Jingzhou Central Hospital, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People’s Republi…

IntroductionEmbryonic stem cells (ESCs), capable of generating all adult cell types, hold transformative potential for agriculture and biomedicine. However, stable sheep ESCs derivation remains challenging, limiting their application in fur…

PURPOSE: To evaluate changes in immunoexpression of proteins involved in epigenetic regulation in the uterus in female ICR mice following neonatal exposure to tamoxifen. METHODS: Thirty-two neonatal mice were randomly assigned to 2 groups:…

Endometriosis (EM) is a condition that impacts roughly 10% of women within the reproductive age demographic on a global scale. Due to the limitations of conventional diagnostic techniques for endometriosis, a concerted effort is necessary t…

ObjectiveTo identify the risk factors for severe primary dysmenorrhea in adolescent girls and provide evidence for clinical prevention and intervention.MethodsThis retrospective study enrolled adolescent girls with primary dysmenorrhea from…

ObjectiveTo estimate the risk of cesarean scar diverticulum associated with the timing of cesarean section.Patients and methodsThis was a retrospective cohort study involving three Chinese hospitals. A total of 11,132 women were included in…