Association between bisphenols A and the risk of endometriosis: results from an updated meta-analysis

Yue Chen, Junle Wu, Yuxin Wang, Fang Wang, Fuke Wang, Qingxin Yang, Yan Zhu, Qin Zhou, Chenyu Sun, Panpan Li
Frontiers in public health · 2026 · vol. 14 , pp. 1817156 · doi:10.3389/fpubh.2026.1817156 · PMID:42158187 · PMC13180928 · W7160098245
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This meta-analysis of seven studies found that bisphenol A exposure is significantly associated with an increased risk of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This updated meta-analysis examined whether bisphenol A (BPA) exposure is associated with endometriosis risk, synthesizing observational studies identified from major English and Chinese databases through August 2025 (registration PROSPERO CRD420251019552). Seven studies totaling 2,488 participants (four case–control, one cohort publication including two cohorts, and one cross-sectional study) were included, with study quality assessed using Newcastle-Ottawa Scale and AHRQ tools and pooled odds ratios calculated with fixed- or random-effects models based on heterogeneity. The meta-analysis found BPA exposure was associated with a statistically significant increase in endometriosis risk (OR = 1.36, 95% CI 1.13–1.63, p = 0.008), and subgroup analyses suggested this association may vary by region, population, and BPA/diagnostic measurement methods; sensitivity analysis supported robustness and publication bias was not detected. This paper is centrally about endometriosis — it specifically meta-analyzes the relationship between bisphenol A exposure and endometriosis risk.

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Abstract

BACKGROUND: Recent studies have disputed the association between bisphenol A (BPA) and endometriosis. This updated meta-analysis was conducted to investigate the impact of BPA exposure on endometriosis. METHODS: This study evaluated BPA exposure and endometriosis risk, analyzing studies from Web of Science, PubMed, Embase, Cochrane Library, and Chinese databases (CNKI, CBM, Wanfang, VIP) through August 2025. Methodological quality was assessed via the Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality Tool (AHRQ). Heterogeneity was quantified using I 2 statistics. Pooled odds ratios (ORs) and 95% CIs were calculated using fixed- or random-effects models according to heterogeneity. Subgroup analysis, sensitivity analysis, and publication bias assessment were supplemented to validate the overall finding. RESULTS: Seven studies comprising 2,488 participants were included in quantitative synthesis. The meta-analyses demonstrated that BPA exposure was associated with a statistically significant increase in endometriosis risk (OR = 1.36, 95% CI = 1.13-1.63, p = 0.008). Additionally, subgroup analysis indicated that BPA exposure may further elevate endometriosis risk in cases with different regions, populations, and measurement methods. Sensitivity analysis confirmed that the results of these meta-analyses were relatively robust. No publication bias was detected. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251019552, identifier PROSPERO (CRD420251019552).

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Condition tags

endometriosis

MeSH descriptors

Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Benzhydryl Compounds Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

SciLite annotations

chemicals 15
bisphenol a xenoestrogen estrogen bisphenol a propane diphenylmethane bisphenol a sodium salt bisphenol a ceftriaxone disodium salt hemiheptahydrate estrogen progesterone oxygen bisphenol a bisphenol a
organisms 5
human noordeloos 2009062 human rodents rodents

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