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Endometrial cancer (EC) incidence is rising, yet current diagnostics lack precision and scalability. We develop an artificial intelligence (AI)-based platform integrating multi-biofluid omics and clinical data for EC stratification. Using t…
ObjectiveWhether large language models (LLMs) can effectively facilitate CM knowledge acquisition remains uncertain. This study aims to assess the adherence of LLMs to Clinical Practice Guidelines (CPGs) in CM.MethodsThis cross-sectional st…
BACKGROUND: Microplastics (MPs) are pervasive environmental pollutants that pose significant health risks. While their prevalence in ecosystems is well-established, their accumulation in the human body and potential role in tumorigenesis de…
Extracellular vesicles (EVs) exert a significant influence not only on the pathogenesis of diseases but also on their therapeutic interventions, contingent upon the variances observed in their originating cells. Mitochondria can be transpor…
AimAcute pancreatitis is an inflammatory disorder of the pancreas, which causes abnormal activation of immune cells. The macrophages were accumulated in pancreas and infiltrated into islets during the AP process to induce abnormal glucose m…
BACKGROUND: Endometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the prec…
High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing need to understand the fu…
The release of inflammatory cytokines, that plays a dominant role in local pancreatic inflammation and systemic complications in severe acute pancreatitis (SAP). High-mobility group box 1 (HMGB1) is implicated in the mechanism of organ dysf…
BACKGROUND: Endometriosis is an enigmatic disease. Gene expression profiling of endometriosis has been used in several studies, but few studies went further to classify subtypes of endometriosis based on expression patterns and to identify …