Michael Koutsilieris

lab-animal 2001

Increased insulin-like growth factor 1 activity can rescue KLE endometrial-like cells from apoptosis

Molecular medicine (Cambridge, Mass.) ·doi:10.1007/bf03401835

BACKGROUND: The peritoneal fluid (PF) of women with endometriosis contains protease(s) activity able to hydrolyze insulin-like growth factor-binding protein 3 (IGFBP-3), increasing the bioavailability of insulin-like growth factor-1 (IGF-1)…

observational 1999

Immunohistochemical localization of insulin-like growth factor-binding protein-3 in eutopic and ectopic endometrial tissues

Fertility and sterility ·doi:10.1016/s0015-0282(99)00443-4

OBJECTIVE: To evaluate the expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in the eutopic endometrium and in endometriotic lesions. DESIGN: Retrospective immunohistochemical study. PATIENT(S): Twenty-five normal women…

other 1997

Association of protease activity against IGFBP-3 with peritoneal fluid mitogens: possible implications for the ectopic growth of endometrial cells in women with endometriosis

Anticancer research

BACKGROUND: Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity. MATERIAL AND METHODS: We characterized mitogens and protease(s) ag…

other 1995

N-terminal truncated forms of insulin-like growth factor binding protein-3 in the peritoneal fluid of women without laparoscopic evidence of endometriosis. Le groupe d'investigation en gynécologie

Fertility and sterility ·doi:10.1016/s0015-0282(16)57362-2

OBJECTIVE: To characterize and purify peritoneal mitogens able to stimulate the proliferation of human endometrial cells in vitro. DESIGN: Peritoneal fluids (PFs) from 50 patients were collected at laparoscopy and pooled (270 mL) for purif…

lab-animal 1993

Heparin-sepharose binding growth factors in peritoneal fluid of women with endometriosis

Fertility and sterility ·doi:10.1016/0020-7292(93)90243-p

OBJECTIVE: To characterize and to purify the growth substances for mouse embryo fibroblasts (NIH/3T3) and endometrial-like cells of the peritoneal fluid of women with endometriosis. DESIGN: A pool of 102 mL of peritoneal fluid (PF) collect…

lab-animal 1993

Heparin-sepharose binding growth factors in peritoneal fluid of women with endometriosis

·doi:10.1016/s0015-0282(16)55621-0

ObjectiveTo characterize and to purify the growth substances for mouse embryo fibroblasts (NIH/3T3) and endometrial-like cells of the peritoneal fluid of women with endometriosis.DesignA pool of 102 mL of peritoneal fluid (PF) collected fro…