V P Dixit

Danazol (28 mg/kg body weight) was administered intramuscularly (i.m.) to intact langurs for a period of 48 days. Epididymides weight showed no significant change but tubular lumina were devoid of spermatozoa. These effects were reversible …

Chronic administration of Danazol (25 mg/kg body wt) caused lesions in the testes of Rattus rattus Rufescens. Depletion of spermatocytes, spermatids and spermatozoa was conspicuous. Impairment of Leydig cell function was correlated with red…

The effects of chemical sterilization with a single injection of Danazol a synthetic (23-isoxazol) derivative of 17-alpah-ethinyl testosterone into the right testis of male dogs were studied. Disorganization of the seminiferous epithelium a…

Danazol administration caused lesions in the seminiferous tubules of gerbils and mice. The seminiferous epithelium became systematically depleted of spermatogonia, spermatocytes, spermatids, and finally spermatozoa. Danazol administration d…

Danazol caused leukolysis in adult female gerbils. It brings about suppression of ovarian weight, presumably by inhibiting gonadotrophin secretion from the pituitary gland. Uterotrophic action of Danazol is confirmed in ovariectomized anima…

The properties of a new synthetic steroid 17-alpha-pregn-4-en-20-yno-(23-d)isoxazol-17-ol (danazol) were investigated in ovariectomized mice and compared with estrogen-treated spayed mice. Danazol alone or in combination with estradiol dipr…