Gao Y

The smooth muscle layer of the uterus (ie, myometrium) is critical for a successful pregnancy and labor. We have shown that the conditional deletion of TGFβ type 1 receptor (TGFBR1) in the female reproductive tract leads to remarkable smoot…

PURPOSE: Over expression of tissue factor (TF) occurs in more than 50 % of colorectal cancer (CRC). Therefore, TF represents an attractive target antigen for immunotherapy in CRC. METHODS: Here, we assessed the safety and efficacy of a rec…

BACKGROUND: Diagnosis of ovarian cancer is often delayed because of subtle symptoms and a lack of a specific, sensitive test useful for the general population. The majority of cases are diagnosed at late stages, after the tumor has metastas…

OBJECTIVE: To evaluate the role of the novel tumor marker human epididymal secretory protein E4 (HE4) in discriminating ovarian cancer from benign pelvic disease in patients with a pelvic mass. METHODS: Serum samples from 131 patients with…

Although it is well known that acupuncture has beneficial effects on a variety of medical conditions especially in pain relief, nausea, and vomiting, it remains controversial whether it has positive impact on the female reproduction. The pr…

BACKGROUND: The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for nodal metastasis a…

OBJECTIVE: To investigate the correlation of endometriotic focus and peritoneal fluid as well as its effect on reproduction. METHODS: Forty-three women with surgical treatment or laproscope with infertility are divided into endometriosis g…

OBJECTIVE: To observe the therapeutic effect of Tripterygium wilfordii Hook. f. on patients with uterine leiomyoma. METHODS: Baseline ultrasound examinations of myomas and uterine were obtained and repeated three months, six months after t…

OBJECTIVE: To investigate the clinical significance of monocyte chemotactic protein-1 (MCP-1) produced by endometriotic tissues. METHODS: Expressions of MCP-1 mRNA and MCP-1 protein were determined by dot blot analysis, immunohistochemical…

To investigate the clinical significance of monocyte chemotactic protein-1 (MCP-1) produced by endometriotic tissues, the endometriotic tissues were taken from 15 patients with endometriosis. MCP-1 mRNA and MCP-1 protein were determined by …

OBJECTIVE: To clarify whether apoptosis is involved in endometriosis and the effects of estradiol, progesterone and mifepristone on the expression of epidermal growth factor receptor(EGFR) in cultured human endometriotic cells. METHODS: Ap…