Zhi-Xiong Huang

No ORCID on file · 8 papers in corpus · active 2017-2025

Study types

  • article 5
  • other 3

Condition tags

  • endometriosis 8
  • infertility 2
  • dysmenorrhea 1
other 2025
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner
Molecular medicine (Cambridge, Mass.) ·doi:10.1186/s10020-025-01130-8

BACKGROUND: Endometriosis (EMs) is a condition characterized by the growth of endometrial tissue outside the uterine cavity. Although this condition is benign, it has cancer-like features. N6-methyladenosine (m6A) is a common RNA modificati…

other 2024
The dysfunction of CD8+ T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis
Immunology ·doi:10.1111/imm.13786

Endometriosis is defined as an oestrogen-dependent and inflammatory gynaecological disease of which the pathogenesis remains unclear. This study aimed to investigate the cellular heterogeneity and reveal the effect of CD8+ T cells on the pr…

article 2022
Lipoxin A4 depresses inflammation and promotes autophagy via AhR/mTOR/AKT pathway to suppress endometriosis
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13659

BACKGROUND: Endometriosis is a benign gynecological disease with the feature of estrogen dependence and inflammation. The function of autophagy and the correlation with inflammation were not yet revealed. METHODS: Autophagosomes were detec…

other 2020
Establishment and characterization of immortalized human eutopic endometrial stromal cells
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13213

PROBLEM: The application of primary eutopic endometrial cells from endometriosis patients in research is restricted for short life span, dedifferentiation of hormone responsiveness. METHOD OF STUDY: Human telomerase reverse transcriptase (…

article 2020
Establishment of an immortalized stromal cell line derived from human Endometriotic lesion
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-020-00669-x

BACKGROUND: Endometriosis is a benign gynecological disease with obviously feature of estrogen-dependence and inflammatory response. The applications of primary endometriotic stromal cells in research of endometriosis are restricted for sho…

article 2020
RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis
Journal of cellular and molecular medicine ·doi:10.1111/jcmm.15689

Abstract Endometriosis is a benign gynaecological disease appearing with pelvic pain, rising dysmenorrhoea and infertility seriously impacting on 10% of reproductive‐age females. This research attempts to demonstrate the function and molecu…

article 2018
High expression of ZEB1 in endometriosis and its role in 17β-estradiol-induced epithelial-mesenchymal transition.
International journal of clinical and experimental pathology

Endometriosis is an estrogen-dependent disease associated with pain and infertility. The objective of this study was to determine the expression of ZEB1 in endometriosis and its role in 17β-estradiol (E2)-induced epithelial-mesenchymal tran…

article 2017
Lipoxin A4 Suppresses Estrogen-Induced Epithelial-Mesenchymal Transition via ALXR-Dependent Manner in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719117718271

ObjectiveEpithelial-mesenchymal transition (EMT) is essential for embryogenesis, fibrosis, and tumor metastasis. Aberrant EMT phenomenon has been reported in endometriotic tissues of patients with endometriosis (EM). In this study, we furth…