Tsuno A

No ORCID on file · 8 papers in corpus · active 2009-2011

Study types

  • article 6
  • review 2

Condition tags

  • endometriosis 8
review 2011
Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719110392059

Endometriosis, a disease affecting 3% to 10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue under the influence of estrogen. It is also becoming recognized as a condition in which ectopic endometr…

article 2011
Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target
Human Reproduction ·doi:10.1093/humrep/der203

BACKGROUND: Accumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. We investigated the histone acetylation status in endometriosis and the application of the histone deac…

article 2011
Fasudil Inhibits the Proliferation and Contractility and Induces Cell Cycle Arrest and Apoptosis of Human Endometriotic Stromal Cells: A Promising Agent for the Treatment of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2011-1503

CONTEXT: During the development of endometriotic lesions, excess fibrosis may lead to scarring and to the alterations of tissue function that are the characteristic features of this disease. Enhanced extracellular matrix contractility of en…

article 2010
Attachment to extracellular matrices is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2010.10.026

ObjectiveEndometriosis is characterized by the ectopic growth of endometrial tissue. One of the first steps to the spread of endometriosis in the peritoneal cavity is the attachment of endometriotic cells to peritoneal surfaces after they h…

article 2009
Decidualization Attenuates the Contractility of Eutopic and Ectopic Endometrial Stromal Cells: Implications for Hormone Therapy of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2009-0207

CONTEXT: Decidualization of the endometrium involves the morphological and biochemical reprogramming of the estrogen-primed proliferative endometrial stromal compartment under the continuing influence of progesterone. OBJECTIVES: The aim of…

article 2009
Heparin is a promising agent for the treatment of endometriosis-associated fibrosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.02.057

ObjectiveTo assess the use of heparin for the medical treatment of endometriosis-associated fibrosis.DesignThe effects of heparin on the endometriotic stromal cells (ECSCs)-mediated contractility were investigated.SettingResearch laboratory…

review 2009
Involvement of resistance to apoptosis in the pathogenesis of endometriosis.
Histology and histopathology ·doi:10.14670/hh-24.1181

Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Increasingly, endometriosis is also becoming recognized as a condition in which ectopic endometrial cells e…

article 2009
Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.06.055

Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is c…