Shengsheng Yang

No ORCID on file · 3 papers in corpus · active 2008-2013

Study types

  • article 3

Condition tags

  • endometriosis 1
article 2013
Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2013.07.006

Background and objectivesPuerarin, a phytoestrogen with a weak estrogenic effect, binds to estrogen receptors, thereby competing with 17β-estradiol and producing an anti-estrogenic effect. In our early clinical practice to treat endometrios…

article 2012
Puerarin Suppresses Proliferation of Endometriotic Stromal Cells Partly via the MAPK Signaling Pathway Induced by 17ß-estradiol-BSA
PloS one ·doi:10.1371/journal.pone.0045529

BACKGROUND: Puerarin is a major isoflavonoid compound extracted from Radix puerariae. It has a weak estrogenic action by binding to estrogen receptors (ERs). In our early clinical practice to treat endometriosis, a better therapeutic effect…

article 2008
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association ·doi:10.1016/j.fct.2008.09.045

Aromatase P450 (P450(arom)) is overexpressed in endometriosis, endometrial cancers and uterine fibroids. With weak estrogen agonists/antagonists and some other enzymatic activities, isoflavones are increasingly advocated as a natural altern…