Ding L

No ORCID on file · 44 papers in corpus · active 2004-2026

Study types

  • other 4
  • article 3
  • review 2
  • case-report 1
  • letter 1

Condition tags

  • endometriosis 5
  • adenomyosis 5
  • infertility 4
  • dysmenorrhea 2
review 2020
Current drug targets ·doi:10.2174/1389450121666200228112344

BACKGROUND: Endometriosis (EMS) is a gynecological disease defined by the translocation and growth of endometrial tissue in other tissues or organs outside the uterus. Its clinical manifestations are dysmenorrhea, irregular menstruation, an…

2020
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-020-01900-9

PurposeTo evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF).MethodsEndometrial miRNA and mRNA expression profiles during the implantation window derived from wom…

2019
EBioMedicine ·doi:10.1016/j.ebiom.2019.10.018

BackgroundRecurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for…

other 2019
Biology of reproduction ·doi:10.1093/biolre/ioz026

Impaired decidualization has been considered a major cause of infertility in adenomyosis. However, the mechanism remains poorly understood. Recent studies suggest that microRNAs (miRNA) play a crucial role in embryo implantation. The aim of…

case-report 2019
Gynecology and minimally invasive therapy ·doi:10.4103/GMIT.GMIT_115_18

Adenomyosis is a commom gynecological disease, which affects women from 30 to 50 years old with the symptoms of dysmenorrhea or menorrhagia. In the past, we always use hysterectomy to treat patients even young women, but now after years of …

2018
Stem cell research & therapy ·doi:10.1186/s13287-018-0904-3

BackgroundIntrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell treatment options using diffe…

other 2018
Cell death & disease ·doi:10.1038/s41419-018-0317-3

Endometriosis (ENDO) is a common gynecological disease that causes infertility in many women. Previous studies noted that the dysregulation of Homeo box A10 (HOXA10) in the endometrium of women with ENDO was involved in the failure of embry…

2018
Cell death discovery ·doi:10.1038/s41420-018-0088-8

Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endomet…

2017
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-017-0260-7

BackgroundA receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined…

2017
Gynecology and Minimally Invasive Therapy ·doi:10.1016/j.gmit.2017.01.001

ObjectiveTo evaluate the effects of different treatment methods for previous ectopic pregnancies (EP) on cryopreserved embryo transfer (CET) outcomes.Materials and methodsThis was a retrospective cohort study. Patients with EP histories wer…

2017
Cell death discovery ·doi:10.1038/cddiscovery.2017.57

HOXA10 has emerged as an important molecular marker of endometrial receptivity. Recurrent implantation failure (RIF) after in vitro fertilization-embryo transplantation (IVF-ET) treatment is associated with impaired endometrial receptivity,…

2017
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-017-0243-8

BackgroundDecidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppe…

other 2016
Molecular human reproduction ·doi:10.1093/molehr/gaw042

STUDY QUESTION: How do NR4A receptors drive decidualization of human endometrial stromal cells (hESCs)? SUMMARY ANSWER: NR4A receptors modulate endometrial decidualization by transcriptional activation of FOXO1A, and in adenomyosis patient…

2015
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-015-0079-z

BackgroundDecidualization is a prerequisite for successful implantation and the establishment of pregnancy. Krüppel-like factor 12 (KLF12) is a negative regulator of endometrial decidualization in vitro. We investigated whether KLF12 was as…

article 2015
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-015-0019-y

BACKGROUND: The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we ex…

letter 2014
International journal of colorectal disease ·doi:10.1007/s00384-014-1987-7
article 2013
Gynecologic and obstetric investigation ·doi:10.1159/000355101

AIMS: To study the effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile patients. METHODS: We performed a retrospective, database-searched cohort study based on 10,268 patients un…

2012
Cell ·doi:10.1016/j.cell.2012.08.024

We report the results of whole-genome and transcriptome sequencing of tumor and adjacent normal tissue samples from 17 patients with non-small cell lung carcinoma (NSCLC). We identified 3,726 point mutations and more than 90 indels in the c…

other 2004
American journal of physiology. Endocrinology and metabolism ·doi:10.1152/ajpendo.00200.2004

Gonadotropin-releasing hormone analog (GnRHa) is used for medical management of endometriosis and premature luteinizing hormone surge during controlled ovarian stimulation. Human endometrium expresses GnRH receptors, and GnRHa alters the ex…