McLaren J

No ORCID on file · 5 papers in corpus · active 1996-2000

Study types

  • article 3
  • other 1
  • review 1

Condition tags

  • endometriosis 5
  • infertility 1
review 2000
Vascular endothelial growth factor and endometriotic angiogenesis
Human reproduction update ·doi:10.1093/humupd/6.1.45

Peritoneal endometriosis is a significant debilitating gynaecological problem of widespread prevalence. It is now generally accepted that the pathogenesis of peritoneal endometriosis involves the implantation of exfoliated endometrium. Esse…

article 1997
Decreased levels of the potent regulator of monocyte/macrophage activation, interleukin-13, in the peritoneal fluid of patients with endometriosis
Human Reproduction ·doi:10.1093/humrep/12.6.1307

Endometriosis is characterized by an increase in the number, activation and secretory activity of peritoneal fluid macrophages. Factors regulating the activation of these cells may be important in the pathophysiology of this disease. In thi…

article 1997
Immunolocalization of the apoptosis regulating proteins Bcl-2 and Bax in human endometrium and isolated peritoneal fluid macrophages in endometriosis
Human Reproduction ·doi:10.1093/humrep/12.1.146

Endometriosis, a debilitating disease associated with infertility, is characterized by the prolonged presence of ectopic endometrial tissue and the involvement of activated peritoneal fluid macrophages. Apoptosis, which occurs in both endom…

article 1996
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
The Journal of clinical investigation ·doi:10.1172/jci118815

Angiogenesis is important in the pathophysiology of endometriosis, a condition characterized by implantation of ectopic endometrium in the peritoneal cavity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved i…

other 1996
Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis
Human Reproduction ·doi:10.1093/oxfordjournals.humrep.a019023

Active endometriosis is characterized by hypervascularization both within and surrounding the implant; therefore the presence of angiogenic factors in the peritoneal environment would be of great importance. Vascular endothelial growth fact…