Rosenfeld CS

No ORCID on file · 5 papers in corpus · active 2008-2021
2021
Biology of reproduction ·doi:10.1093/biolre/ioab147

Histone proteins undergo various modifications that alter chromatin structure, including addition of methyl groups. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that methylates lysine residue 27, and thereby suppresses …

2020
Physiological genomics ·doi:10.1152/physiolgenomics.00098.2019

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that suppresses gene expression. Previously, we developed a conditional null model where EZH2 is knocked out in uterus. Deletion of uterine EZH2 increased proliferation of lu…

2020
Epigenomes ·doi:10.3390/epigenomes4030020

Epigenetic modifications regulate normal physiological, as well as pathological processes in various organs, including the uterus and placenta. Both organs undergo dramatic and rapid restructuring that depends upon precise orchestration of …

2018
Frontiers in endocrinology ·doi:10.3389/fendo.2018.00610

Diverse cognitive functions in many vertebrate species are influenced by local conversion of androgens to 17β-estradiol (E2) by aromatase. This enzyme is highly expressed in various brain regions across species, with some inter-species vari…

2008
Journal of molecular endocrinology ·doi:10.1677/jme-08-0029

Selective estrogen receptor modulators (SERMs) are potentially useful in treating various endometrial disorders, including endometrial cancer, as they block some of the detrimental effects of estrogen. It remains unclear whether each SERM r…