Junyan Ma

Endometriosis affects a substantial number of women of reproductive age, yet current diagnostic methods rely on invasive procedures. To address this limitation, we investigated THBS1 as a potential biomarker and regulator of disease progres…

Increasing evidences showed that ovulatory dysfunction, possibly caused by luteinized unruptured follicular follicle syndrome (LUFS), is one of the reasons for endometriosis-related infertility. The present study was conducted to explore th…

Additional file 10. Differentially expressed genes of all M cells subclusters.

Additional file 11. Differentially expressed genes of FB clusters among endometriosis lesions, eutopic endometrium, and normal endometrium.

Additional file 12. Differentially expressed genes of CD4+ T cells along the pseudotime trajectory.

Additional file 1: Figure S1. Study flow chart. Single-cell RNA-sequencing. Figure S2 a-g. Enriched functions of FBs, Eps, ECs, T cells, NK cells, M cells, ast cells and neutrophils by GO and KEGG analyses. Figure S3. Single-cell RNA-seq an…

Additional file 3. Differentially expressed genes of FBs, M cells, NK cells, T cells, ECs, Eps, mast cells, and neutrophils.

Additional file 4. Differentially expressed genes of all FBs subclusters.

Additional file 5. Differentially expressed genes of FBs along the pseudotime trajectory.

Additional file 6. The relative ratio of immune cells in endometriosis lesions, eutopic endometrium, and normal endometrium.

Additional file 7. Differentially expressed genes of all T cells subclusters.

Additional file 8. The relative ratio of T cells subclusters in endometriosis lesions, eutopic endometrium, and normal endometrium.

Additional file 9. Differentially expressed genes of all NK cells subclusters.

Abstract Background: Luteinized unruptured follicular follicle syndrome (LUFS) is a special type of ovulatory dysfunction and a common cause of infertility. It is estimated that its prevalence is 13% ~ 73% in endometriosis patients. Increa…

BACKGROUND: Endometriosis is a benign gynecological disease that shares some characteristics with malignant tumors and affects approximately 10% of women of reproductive age. Endometrioma refers to endometriosis that appears in the ovary. M…

BACKGROUND: Endometriosis is an oestrogen-dependent disease with an unclear aetiology and pathogenesis affecting 6-10% of the global female population, predominantly those of reproductive age. Herein, we profile the transcriptomes of approx…

OBJECTIVE: To investigate the role(s) of hyaluronan synthase 2 (HAS2) and hyaluronan in disease progression of endometriosis and epidermal growth factor (EGF)-induced motility changes of endometriotic cells. DESIGN: A case-control experime…

The purpose of this study was to integrate the existing expression profile data on endometriosis (EM)-related tissues in order to identify the differentially expressed genes. In this study, three series of raw expression data were downloade…

BackgroundEndometriosis is a benign gynaecological disease with malignant characteristics that severely affects women's quality of life. Long noncoding RNA maternally expressed gene 3 (LncRNA MEG3) is a tumour suppressor that is downregulat…

Interleukin (IL)-34 plays a critical role in cell proliferation, differentiation, apoptosis, angiogenesis, inflammation and immunoregulation. Numerous diseases can be attributed to the dysregulation of IL-34 signaling. This study was perfor…

Research questionEndometriosis is characterized by the occurrence of endometrial-like tissue outside the uterus. Collagen triple helix repeat containing-1 (CTHRC1) is known as a tumour-promoting factor in several neoplasms. This study aimed…

The purpose of this study was to investigate the difference of Twist gene promoter methylation among ovarian ectopic endometrium, eutopic endometrium and non-endometriosis (EMs) endometrium . 15 patients with reproductive age hospitalized a…

AIM: To investigate the roles of cell migration and invasion mediated by Twist in endometriosis. METHODS: The protein levels and locations of Twist, N-cadherin and E-cadherin were measured by Western blot and immunohistochemistry in ectopic…

The activation of systemic and local inflammatory mechanisms, including elevated levels of chemokines and proinflammatory cytokines in endometriosis progression, is becoming more evident in the recent years. Here, we report the involvement …