Wang C

BackgroundImmature teratoma is a malignant tumor and accounts for 1%-3% of ovary teratoma. The objective of this study was to find the potential single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and drug targets in the i…

IntroductionTranscription factor EB (TFEB) deficiency contributes to insufficient autophagic degradation, resulting in zymogen granule (ZG) accumulation and subsequent premature activation, which underlies the pathogenesis of alcoholic panc…

β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …

BackgroundPolycystic ovary syndrome (PCOS) is widely acknowledged as the prevailing reproductive endocrine disorder accompanied by numerous metabolic dysfunctions. However, there has been a lack of systematic examination regarding the amino…

PurposeThis study aims to assess the impact of ultrasound parameters on endometrial receptivity in patients undergoing IVF-ET and to establish a predictive model for ongoing pregnancy outcomes.MethodsThe prospective cohort study included 86…

High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign samples to balanced batches, m…

High throughput sequencing is a powerful tool for processing large amounts of DNA and RNA samples in batches. Proper experimental design and statistical methods are required to mitigate systematic technical factors due to differences in bat…

PurposeThe International Federation of Gynecology and Obstetric (FIGO) stage is critical to guiding the treatments of ovarian cancer (OC). We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms with …

BackgroundAlthough the cardiometabolic index (CMI) has gained recognition as a new tool for evaluating metabolic health, the relationship between CMI and cardiovascular disease (CVD) remains unclear. This research sought to explore the pote…

Air pollution has reproductive toxicity, while green space could lessen such harmful consequences. However, the current research on the link between air pollution/green space, and endometriosis remains scarce. Therefore, we investigated the…

BackgroundThe potentially risky effects of metabolites of phthalates (mPAEs) on inflammation and immune function have attracted much attention in recent years. However, direct studies on the relationship between these metabolites and the sy…

BACKGROUND: Endometriosis is a chronic gynecological disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, causing chronic pain and infertility. Hypoxia plays a significant role in the progression of …

BACKGROUND: Dysmenorrhea and menstrual disorders caused by endometriosis (EM) and adenomyosis (AM) have significantly affected the quality of life of a large number of women. As a highly effective clinical contraceptive measure, etonogestre…

BACKGROUND: Previous studies have shown that due to the presence of endometrium progesterone resistance in patients with endometriosis, it is considered that higher levels of progesterone may be required to achieve live birth during program…

OBJECTIVES: Endometriosis is a common chronic disease in childbearing women and a major cause of infertility. Our study aimed to identify and validate a novel gene signature for diagnosing endometriosis based on histone-related genes (HRGs)…

ObjectiveThe causative role of gut microbiota in pancreatitis remains unknown. This study aimed to investigate potential causal associations between gut microbiota and pancreatitis, using bidirectional Mendelian randomization (MR) analysis.…

Vulvar lichen sclerosus (VLS) is a chronic skin condition affecting the vulva, causing significant discomfort, but its etiology in prepubertal girls remains poorly understood. VLS presents with itching, irritation, and pain. Recent studies …

Spatial transcriptomics enables in situ molecular profiling, allowing to measure the cellular transcriptional output within the tissue. As the tissue architecture is conserved, spatial domains with specific transcriptional patterns can be i…

ObjectiveTo investigate the benefits of menstrual management in women undergoing hematopoietic stem cell transplantation (HSCT), in whom heavy menstrual bleeding (HMB) can be an underestimated bleeding complication.MethodsThis was a retrosp…

BackgroundPolycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of …

BackgroundOvarian cancer is a highly lethal gynecological malignancy, with epithelial ovarian cancer (EOC) being its most common form. Surgery combined with chemotherapy is the standard treatment. Resection completeness significantly impact…

BackgroundOvarian cancer (OV) is the deadliest gynecologic malignancy owing to its late diagnosis and high metastatic propensity. Current biomarkers lack sufficient sensitivity and specificity for the detection of early-stage cancer. To add…

IntroductionPrimary dysmenorrhea (PD) is characterized by pain during the menstrual cycle, affects women's health. Our group developed a traditional Chinese medicine plaster (Wentong plaster, WTT) for the treatment of PD. However, the under…

Infertility poses considerable challenges to both the endocrine system and psychological well-being of affected women. In particular, those undergoing Assisted Reproductive Technology (ART) confront not only physiological demands but also s…

ObjectiveAdvanced gastric cancer remains highly refractory to therapy, with limited immunotherapy efficacy due to tumor microenvironment heterogeneity. Primary cilia, microtubule-based organelles involved in tumor progression, remain insuff…