Agarwal SK

Endometriosis affects approximately 10% of reproductive-age women worldwide and is associated with substantial pain and mental health burden, yet its neurobiological correlates remain poorly characterized. Neuroimaging studies of endometrio…

Endometriosis is a common disease, affecting approximately 5-10% of reproductively aged women. Symptoms, such as painful periods, negatively impact an individual's quality of life; however, these symptoms are often normalized, leading to de…

Renee T Sullender,1 Ravi K Agarwal,2 Marni B Jacobs,1 Jocelyn M Wessels,3 Warren G Foster,3 Sanjay K Agarwal1 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Diego, La Jolla, CA, USA; 2Univer…

PURPOSE: To evaluate the impact of an interleukin-1 (IL-1) antagonist anakinra (Kineret®) on endometriosis-related quality of life (QoL), pain, and inflammatory biomarkers. METHODS: This was a single-site, randomized, double-blinded, place…

BackgroundHistorically, the clinical characteristics and treatment pathways for patients with uterine fibroids and heavy menstrual bleeding have differed between White and Black women.ObjectiveTo provide a contemporary comparison of patient…

Elke Hunsche,1 Martha Gauthier,2 Brooke Witherspoon,2 Viatcheslav Rakov,1 Sanjay K Agarwal3 1Myovant Sciences GmbH, Basel, Switzerland; 2Endpoint Outcomes, A Lumanity Company, Boston, MA, USA; 3Center for Endometriosis Research and Treatmen…

Renee T Sullender,1 Marni B Jacobs,1 Manpreet S Sandhu,2 D Yvette Lacoursiere,1 Carolina Diaz Luevano,1 Charlotte M Pickett,1 Sanjay K Agarwal1 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San…

Endometriosis is a common gynecological condition characterized by estrogen dependence, chronic pelvic pain, infertility, and diagnostic delay of between 5.4 and 12 years. Despite extensive study, no biomarker, either alone or in combinatio…

Endometriosis is a chronic, estrogen-dependent gynecological condition affecting approximately 10% of reproductive age women. The most widely accepted theory of its etiology includes retrograde menstruation. Recent reports suggest the uteru…

BACKGROUND: Women with endometriosis are commonly treated by their sole provider. In this single-provider model of care, women frequently report long diagnostic delays, unresolved pelvic pain, multiple laparoscopic surgeries, sequential con…

BACKGROUND: Dyspareunia experienced by women diagnosed with endometriosis is associated with a decreased health-related quality of life (HRQoL). AIM: We evaluated the relationship of clinically meaningful improvements in dyspareunia with HR…

Circulating concentrations of brain-derived neurotrophic factor (BDNF) have been linked to cancer, neuropsychiatric, diabetes, and gynecological disorders. However, factors influencing plasma storage and subsequent BDNF quantification are i…

INTRODUCTION: We evaluated elagolix and leuprolide from the patient's perspective for the treatment of endometriosis-related pain. AREA COVERED: Preference weights from a published discrete choice experiment were used to evaluate preference…

ObjectivesTo quantify patient preferences for endometriosis-associated pain treatments and risk tolerance in exchange for pain reduction and to explore whether preferences vary on the basis of patient characteristics.MethodsUS women with a …