Zhou Z

Laparoscopic gynecological surgery, despite its minimally invasive nature, is frequently associated with significant postoperative pain, encompassing somatic, visceral, and referred components. This pain poses challenges to patient recovery…

OBJECTIVE: To develop and validate a multiparametric diagnostic model for adenomyosis utilizing standardized cervical anatomical landmarks. By integrating cervical shear wave elastography (SWE) and ultra-microangiography (UMA), this study a…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and a major cause of anovulatory infertility, often requiring assisted reproductive technology (ART). The freeze-all strategy followed by frozen-thawed embryo tr…

STUDY QUESTION: How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches? SUMMARY ANSWER: This exploration of the gut-reproductive axis in patients with endometriosis found…

OBJECTIVE: To investigate the efficacy of goserelin (GOS) combined with laparoscopic surgery (LS) in the treatment of endometriosis (EMS), and its effects on ovarian function and oxidative stress (OS). METHODS: A total of 208 patients with…

Endometriosis (EM) and chronic endometritis (CE) are both implicated in female infertility, yet the relationship between them remains incompletely understood. In this narrative review, we synthesize non-systematically selected clinical and …

Endometriosis (EM) is an intractable gynecological condition with uncertain etiology. Gut microbiota have been increasingly implicated in EM, yet the underlying mechanisms remain unclear. Here, we identify a gut microbe-metabolite-uterus ax…

BACKGROUND: The single-incision laparoscopic cholecystectomy (SILC) achieves a scarless appearance through a single umbilical approach. However, the restricted surgical field of view, frequent instrument collisions limit its clinical applic…

High-throughput omics technologies have transformed our understanding of female reproductive biology, revealing molecular interactions governing oocyte maturation, ovarian reserve, endometrial receptivity, and embryo development, yet most f…

Endometrial polyps (EPs) are common uterine lesions associated with abnormal uterine bleeding and infertility, yet their pathogenesis remains poorly defined. Here, we performed single-cell RNA sequencing of normal endometrium, para-polyp, a…

PURPOSE: Temporary ileostomy is commonly performed to protect rectal anastomosis after rectal surgery, yet the optimal timing of reversal remains unsettled. This study compared postoperative outcomes among early, intermediate, and late ileo…

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is systematically com…

BACKGROUND: Abdominal pregnancy refers to the implantation of a fertilized egg in the abdominal cavity outside of the uterus, fallopian tubes, and ovaries; splenic pregnancy is a rare type of abdominal pregnancy. CASE PRESENTATION: Our pat…

BACKGROUND: Endometrial fibrosis can disrupt the uterine junctional zone and lead to infertility. Accurate and noninvasive evaluation of junctional zone alterations is important to clinical treatment. Although conventional T2-weighted imagi…

Introduction. Endometriosis affects 10-20% of reproductive-age women. Emerging evidence links the gut microbiota to endometriosis pathogenesis, but observational studies are limited by confounding, reverse causation and uncertainty about wh…

Endometriosis (EMS) is characterised by a disrupted peritoneal immune microenvironment where M2 macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-seq (ScRNAseq) of the peritoneal macrophages from EMS…

Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains unc…

BackgroundAs the main cause of maternal deaths in early pregnancy, delayed diagnosis of ectopic pregnancy (EP) may lead to severe consequences. Patients with pregnancy of unknown location (PUL) exhibit a significantly higher incidence of EP…

Abstract Endometriosis is a chronic gynecological condition influenced by inflammation and oxidative stress. Dietary vitamin B1 plays a role in reducing oxidative stress, which may influence endometriosis risk. However, limited research exp…

BACKGROUND: Ovarian maldescent is a rare congenital anomaly in which one or both ovaries are positioned abnormally above the pelvic brim. However, the potential relationship between ovarian maldescent and infertility remains poorly understo…

Myocardial infarction (MI) is one of the most serious cardiovascular diseases in the world. Nevertheless, the majority of diagnostic procedures conducted subsequent to the illness do not provide any means to prevent several risks associated…

This study investigates changes in regional homogeneity (ReHo) of the brain in patients with adenomyosis accompanied by dysmenorrhea (AMD) before and after uterine artery embolization (UAE) surgery. ReHo is a resting-state functional magnet…

BACKGROUND: Assisted reproductive technology (ART) effectively treats infertility yet often results in multiple pregnancies. Optimizing clinical pregnancy rates while minimizing multiples remains challenging. Key considerations for ART prov…

Endometriosis is a chronic inflammatory disorder in which immune cells, specifically macrophages, play a pivotal yet incompletely understood role. Aberrations within the eutopic endometrium are implicated in the initiation and progression o…

BACKGROUND Gastric cancer with features of submucosal tumor (GCSMT) is extremely rare and often manifested as poorly differentiated or undifferentiated types, including poorly differentiated adenocarcinoma and gastric signet ring cell carci…