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ObjectiveTo examine the relationship of ovulation-stimulating drugs to risk of cancers other than breast and gynecologic malignancies.DesignRetrospective cohort study, with additional follow-up since initial report.SettingReproductive endoc…
BackgroundAlthough fertility drugs stimulate ovulation and raise estradiol levels, their effect on breast cancer risk remains unresolved.MethodsAn extended follow-up was conducted among a cohort of 12,193 women evaluated for infertility bet…
Study questionDo fertility drugs influence the subsequent risk of endometrial cancer in a manner that is independent of other risk predictors, such as parity?Summary answerIn this follow-up of a large cohort of women evaluated for infertili…
ObjectiveTo examine the relationship of ovulation-inducing drugs and ovarian cancer.DesignRetrospective cohort study, with additional follow-up since initial report.SettingFive large reproductive endocrinology practices.Patient(s)In a retro…
PurposeAntiepileptic drugs (AEDs) are widely used in reproductive-age women. The AED carbamazepine (CBZ) induces the hepatic cytochrome P450 system, thereby accelerating hormone metabolism. We sought to assess the pharmacodynamic effects of…
BACKGROUND: Although studies have found elevated risks of certain cancers linked to infertility, the underlying reasons remain unclear. METHODS: In a retrospective cohort study of 12,193 U.S. women evaluated for infertility between 1965 and…
ObjectiveTo evaluate the risk of ovarian cancer as related to underlying causes of infertility.DesignRetrospective observational cohort study.SettingFive large reproductive endocrinology practices.Patient(s)A total of 12,193 women evaluated…