Hideki Tokunaga
No ORCID on file
· 13 papers in corpus
· active 2007-2026
Study types
- article 5
- review 4
- other 2
Condition tags
- endometriosis 9
Top journals
Frequent coauthors
- Serdar E. Bulun 8
- Tokunaga H 7
- Bulun SE 6
- Erkut Attar 6
- Mary Ellen Pavone 5
- Bilgin Gürateş 4
- Qing Xue 4
- Gonca İmir 4
- Emily J Su 4
- Attar E 4
article
2026
BACKGROUND: Mucinous borderline ovarian tumors (MBOTs) are rare neoplasms with excellent prognosis, yet the optimal surgical extent remains controversial. No large-scale study in Japan has evaluated treatment trends and prognostic factors f…
2025
ObjectiveThis multi-center retrospective study aimed to clarify the characteristics, diagnostic accuracy, treatment outcomes, and prognostic factors of uterine serous carcinoma (USC) in Japanese women.MethodsThe medical records of 193 patie…
2023
BackgroundEndometrial cancer is one of the most common gynecological malignancies. Because the findings mentioned in radiogram interpretation reports issued by diagnostic radiologists influence treatment strategies, we aimed to evaluate the…
other
2018
Ovarian clear cell carcinoma (OCCC) is the most refractory subtype of ovarian cancer and more prevalent in Japanese than Caucasians (25% and 5% of all ovarian cancer, respectively). The aim of this study is to discover the genomic alteratio…
article
2018
Endometriotic stromal cells synthesize estradiol via the steroidogenic pathway. Nuclear receptor subfamily 5, group A, member 1 (NR5A1) is critical, but alone not sufficient, in activating this cascade that involves at least 5 genes. To eva…
review
2012
Endometriosis is an estrogen-dependent disease. The biologically active estrogen, estradiol, aggravates the pathological processes (e.g., inflammation and growth) and the symptoms (e.g., pain) associated with endometriosis. Abundant quantit…
other
2011
Approximately half of women with endometriosis achieve pain relief from existing medical or surgical treatments. Medical treatments are usually directed at inhibiting estrogen action or its production from the ovaries and do not address loc…
review
2010
Estradiol (E2) stimulates the growth and inflammation in the ectopic endometriotic tissue that commonly resides on the pelvic organs. Several clinical and laboratory-based observations are indicative of resistance to progesterone action in …
review
2010
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progest…
article
2009
ContextProducts of at least five specific steroidogenic genes, including steroidogenic acute regulatory protein (StAR), which facilitates the initial entry of cytosolic cholesterol into the mitochondrion, side-chain-cleavage enzyme (P450scc…
article
2008
CONTEXT: Products of at least five specific steroidogenic genes, including steroidogenic acute regulatory protein (StAR), which facilitates the entry of cytosolic cholesterol into the mitochondrion, side chain cleavage P450 enzyme, 3beta-hy…
review
2008
Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertility. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes includ…
article
2007
Malignant ovarian neoplasms derived from ovarian epithelium that produce estrogen are rare among postmenopausal women. Presented herein is a case of stage Ic(a) endometrioid adenocarcinoma in the right ovary of an 81-year-old woman, who com…