S J Holdsworth-Carson

No ORCID on file · 4 papers in corpus · active 2019-2023

Study types

  • article 4

Condition tags

  • endometriosis 4
  • die_deep_infiltrating 1
  • adenomyosis 1
article 2023
A molecular staging model for accurately dating the endometrial biopsy
Nature communications ·doi:10.1038/s41467-023-41979-z

Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the endometrial cycle. Here we develop and validate a method f…

article 2020
Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium
Molecular human reproduction ·doi:10.1093/molehr/gaaa082

The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease risk. Genome-wide association studies (GWAS) have identified multiple signals in the estrogen receptor 1 (ESR1) r…

article 2020
Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium
Human Reproduction ·doi:10.1093/humrep/deaa249

STUDY QUESTION: Do menstrual cycle-dependent changes occur in the histological appearance of superficial peritoneal endometriotic lesions, and are they equivalent to those observed in the eutopic endometrium? SUMMARY ANSWER: Only a small su…

article 2019
Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes
Molecular human reproduction ·doi:10.1093/molehr/gaz006

Endometriotic lesions are composed in part of endometrial-like stromal cells, however, there is a shortage of immortalized human endometrial stromal cultures available for research. As genetic factors play a role in endometriosis risk, it i…