Andrew W. Horne
ORCID: 0000-0002-9656-493X
· 216 papers in corpus
lab-animal
2020
Abstract Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacologi…
2020
observational
2020
Abstract Objective To characterise peritoneal macrophage populations in women with suspected endometriosis and assess if they are correlated with severity of pelvic pain symptoms. Design Flow cytometry analysis of peritoneal fluid samples a…
rct
2020
Background Chronic pelvic pain (CPP) affects 2-24% of women worldwide and evidence for medical treatments is limited. Gabapentin is effective in treating some chronic pain conditions. We aimed to determine the efficacy and safety of gabapen…
2020
other
2020
other
2020
Self-management strategies to consider to combat endometriosis symptoms during the COVID-19 pandemic
The care of patients with endometriosis has been complicated by the coronavirus disease 2019 (COVID-19) pandemic. Medical and allied healthcare appointments and surgeries are being temporarily postponed. Mandatory self-isolation has created…
other
2020
STUDY QUESTION: Is it feasible to undertake a randomised controlled trial to establish whether surgical removal of endometrioma or not, improves live birth rates from IVF? SUMMARY ANSWER: A randomised controlled trial (RCT) comparing surge…
meta-analysis
2020
BACKGROUND: Fibroids are the most common benign tumours of the female genital tract and are associated with numerous clinical problems including a possible negative impact on fertility. In women requesting preservation of fertility, fibroid…
other
2019
INTRODUCTION: Chronic pelvic pain (CPP) - defined as intermittent or constant pain in the lower abdomen or pelvis of at least 6 months' duration, not occurring exclusively with menstruation or intercourse and not associated with pregnancy -…
other
2019
Bougie and colleagues systematically reviewed the current literature on the association between race/ethnicity and endometriosis diagnosis (Bougie et al. BJOG 2019;126:1104–15). Compared with white women, black women were less likely (OR 0.…
observational
2019
OBJECTIVE: To investigate the relationship between endometriosis and adverse pregnancy outcomes. METHODS: Women between ages 25 and 42 years in 1989 (n=116,429) reported detailed information on pregnancies and reproductive health at baseli…
other
2019
lab-animal
2019
Endometriosis is a common incurable inflammatory disorder that is associated with debilitating pelvic pain in women. Macrophages are central to the pathophysiology of endometriosis: they dictate the growth and vascularization of endometrios…
other
2019
lab-animal
2019
Endometriosis is a chronic pain condition affecting ∼176 million women worldwide. It is defined by the presence of endometrium-like tissue (lesions) outside the uterus, most commonly on the pelvic peritoneum. There is no cure for endometrio…
review
2019
Endometriosis is chronic disorder with high socioeconomic impact defined by the presence of endometrial-like tissue ("lesions") outside the uterus. Genetic, hormonal, and immunological factors as well as endometrial progenitor cells are imp…
other
2019
Endometriosis is a potentially life-altering, estrogen-dependent condition which is associated with chronic pelvic pain. It affects an estimated 176 million women worldwide, making it as common as diabetes mellitus (DM).1 The socio-economic…
2019
rct
2019
OBJECTIVE: To inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women. DESIGN: Mechanis…
other
2018
review
2018
Challenges intrinsic to the accurate diagnosis of endometriosis contribute to an extended delay between the onset of symptoms and clinical confirmation. Intraoperative visualization, preferably with histologic verification, is considered by…
other
2018
BACKGROUND: Endometriosis affects 6-10% of women and is associated with debilitating pelvic pain. It costs the UK > £2.8 billion per year in loss of productivity. Endometriosis can be managed by surgical excision or medically by ovarian sup…
rct
2018
INTRODUCTION: Chronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and…
observational
2018
(Abstracted from BJOG 2018;125(1):64–72) The mainstay for the diagnosis and treatment of endometriosis is surgery. After the initial surgery, women often undergo multiple operations in an attempt to alleviate persistent symptoms of pain and…