Aijun Zhang

No ORCID on file · 8 papers in corpus · active 2015-2026

Study types

  • other 3
  • article 2

Condition tags

  • adenomyosis 4
  • endometriosis 1
  • infertility 1
other 2026
Single-cell transcriptomic landscape of the mid-secretory eutopic endometrium reveals receptivity defects in adenomyosis
Journal of translational medicine ·doi:10.1186/s12967-026-07866-z

BACKGROUND: Adenomyosis (AM) is a common gynecological disorder in reproductive-age women, with impaired endometrial receptivity as a key contributor to infertility. However, a comprehensive single-cell atlas of the eutopic endometrium duri…

other 2025
Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis
Molecular medicine (Cambridge, Mass.) ·doi:10.1186/s10020-024-01054-9

Reduced lymphoid enhancer-binding factor 1 (LEF1) expression in patients with adenomyosis during the mid-secretory phase leads to impaired endometrial receptivity, affecting embryo implantation. This study investigated the molecular mechani…

2022
Cell-free fat extract improves ovarian function and fertility in mice with premature ovarian insufficiency.
Stem cell research & therapy ·doi:10.1186/s13287-022-03012-w

BackgroundPremature ovarian insufficiency (POI) is a refractory disease that seriously affects the reproductive health of women and is increasing in incidence and prevalence globally. There is enormous demand to improve fertility in women w…

2022
Decreased CD44v3 expression impairs endometrial stromal cell proliferation and decidualization in women with recurrent implantation failure.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-01042-w

BackgroundThe precise pathogenesis of poor endometrial receptivity in recurrent implantation failure (RIF) remains unclear. This study was aimed at exploring the effects of different CD44 isoforms in the mid-secretory phase endometrium on e…

2021
Down-regulation of S100P induces apoptosis in endometrial epithelial cell during GnRH antagonist protocol.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-021-00787-0

BackgroundThe gonadotropin-releasing hormone (GnRH) antagonist protocol for in vitro fertilization (IVF) often leads to lower pregnancy rates compared to the GnRH agonist protocol. Decreased endometrial receptivity is one reason for the low…

article 2020
Proteomic Analysis of Uterine Tissues During Peri-Implantation Period in Mice with Experimentally Induced Adenomyosis that Treated with anti-Ngf: Implications for Cell-Cell Adhesion and Metabolic Processes
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00262-y

Nerve growth factor (NGF) has been verified to be expressed with higher level in adenomyosis uteri, and its neutralizing antibody has a strong inhibitory influence on inflammation. The present study aimed to explore the effect of anti-NGF o…

other 2017
Systematic identification of the druggable interactions between human protein kinases and naturally occurring compounds in endometriosis
Computational biology and chemistry ·doi:10.1016/j.compbiolchem.2017.10.006

Diverse kinase signaling pathways have been involved in the pathogenesis of endometriosis (EM), which can be modulated either by directly targeting the hub kinases or by indirectly regulating marginal members in the pathways. Here, a system…

article 2015
Cytokine Profiling in the Eutopic Endometrium of Adenomyosis During the Implantation Window After Ovarian Stimulation
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115597761

In this study, we aimed to clarify the inflammatory cytokine profile of endometrium in patients with adenomyosis during the implantation window after ovarian stimulation. Eighteen patients with adenomyosis and 24 control patients undergoing…