Fang Lian

目的 探讨滋肾祛瘀解毒方通过调控NRF2-HO1信号通路改善子宫内膜异位症（EMs）的作用，并从氧化应激角度阐明中医药治疗EMs的机制。 方法 将40只健康未孕SD雌性大鼠随机分为空白组10只、模型组10只，米非司酮组10只，滋肾祛瘀解毒方组10只。使用自体移植法建立大鼠EMs模型，HE染色观察子宫内膜异位病灶组织形态变化；免疫组化法检测 NRF2、HO1、NQO1在细胞中的阳性表达；ELISA法检测大鼠血清SOD、MDA、GSH-PX、8-epi-PGF2α、IL-6…

BackgroundDiminished ovarian reserve (DOR) is associated with impaired female fertility; however, its molecular mechanisms remain incompletely understood. Our previous studies found that individuals with DOR have lower levels of microRNA-37…

ObjectiveTo investigate the efficacy of the Er Zhi Tian Gui Formula (EZTGF) in diminished ovarian reserve (DOR) patients undergoing in vitro fertilization-embryo transfer (IVF-ET); to examine the pharmacological mechanism of EZTGF in inhibi…

PurposeThis study aimed to compare the efficacy of human chorionic gonadotropin (hCG) and dual-trigger (gonadotropin-releasing hormone agonist [GnRH-a] and hCG) protocols in terms of cumulative live birth rate (CLBR) and other pregnancy out…

IN BRIEF: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closel…

OBJECTIVE: Zishen Quyu Jiedu formula (ZQYJDF) is a commonly used prescription for endometriosis (EMs) with clinical efficacy. However, its active components and potential mechanisms remain unknown. This study aimed to identify the key targe…

BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous gynecological endocrine disorder linked to immunity. Cangfu Daotan Decoction (CFDT), a classic Chinese medicine prescription, is particularly effective in treating PCOS, specific…

BackgroundInfertility is a reproductive health problem that attracts worldwide attention. Polycystic ovary syndrome (PCOS) is a major cause of female infertility and patients with obesity and PCOS are particularly common in clinical practic…

BackgroundFemales with diminished ovarian reserve (DOR) have significantly lower cumulative live birth rates (CLBRs) than females with normal ovarian reserve. A subset of young infertile patients, whose ovarian reserve is declining but has …

Abstract Objective This study aims to investigate the expression disparities of Nuclear Receptor Coactivator 4 (NCOA4) in endometriosis (EMS) patients, assessing its diagnostic potential. It also elucidate the correlation between the immu…

BackgroundIn our previous investigation, we revealed a significant increase in the expression of microRNA-6881-3p (miR-6881-3p) in follicular fluid granulosa cells (GCs) from women with diminished ovarian reserve (DOR) compared to those wit…

BackgroundAt present, there are few studies on whether there is reproductive advantage in advanced polycystic ovary syndrome (PCOS) patients, and the existing research results are also controversial. Some research results show that the repr…

The aim of this study is to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement regimen for frozen-thawed embryos. We performed a retrospective cohort study and included patients who underwent frozen embryo t…

IntroductionThe relationships between the outcome of frozen-thaw embryo transfer (FET) cycle and endometrial compaction were not quite consistent.ObjectiveTo analyze the relationship between the outcome of FET cycle and endometrial compacti…

IntroductionLaser-assisted hatching (LAH) is a commonly used adjunct technique; however, its effectiveness has not been fully established.ObjectiveWe evaluated the effects of LAH on pregnancy outcomes in frozen-thawed embryo transfer (FET) …

ObjectiveThis retrospective study aimed to explore whether puncturing and aspirating asynchronized large follicles during long GnRH-a protocol COH impacted IVF-ET outcomes.MethodsA total of 180 patients with asynchronized follicles during l…

BackgroundInfertility is a global reproductive-health problem, and diminished ovarian reserve (DOR) is one of the common causes of female infertility. Long noncoding RNAs (lncRNAs) are crucial regulators of numerous physiological and pathol…

BackgroundDespite a large number of studies on the selection of trigger drugs, it remains unclear whether the dual trigger with human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist, compared to the trigger wi…

BackgroundPrevious studies have shown that frozen embryo transfer (FET) resulted in increased live birth rates (LBR) and reduced the risk of ovarian hyperstimulation syndrome (OHSS) than did fresh embryo transfer in women with polycystic ov…

Background: Previous studies have shown that frozen embryo transfer (FET) resulted in increased live birth rates (LBR) and reduced the risk of ovarian hyperstimulation syndrome (OHSS) than did fresh embryo transfer in women with polycystic…

BackgroundGonadotropin-releasing hormone antagonist(GnRH-ant) has been shown to have a negative effect on endometrial receptivity. Therefore, the use of lower doses of GnRH-ant during controlled ovarian stimulation (COS) may improve endomet…

BackgroundPolycystic ovary syndrome (PCOS) is a complex disorder associated with multiple metabolic disturbance, including defective glucose metabolism and insulin resistance. The altered metabolites caused by the related metabolic disturba…

BACKGROUND: Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived neurotrophic factor (GDNF) are soluble polypeptide growth factors …

Background: Endometriosis is a common gynecological disease defined as the presence of endometri - oid tissue (glands and stroma) outside the uterus. About 30 to 40% patients with endometriosis are infertile. In traditional Chinese medical …