Harald Seeger

OBJECTIVES: Dienogest (DNG) is already used in hormone therapy, since recently being also the progestogenic component of the first estradiol based contraceptive pill. Data on breast cancer risk are currently not available. Progesterone rece…

Dienogest (DNG) has the essential properties of an effective progestogen for use in a new contraceptive pill using estradiol valerate as estrogenic component -- it inhibits ovulation and protects against endometrial proliferation. DNG is a …

OBJECTIVE: Recent clinical studies indicate that an increase in D-ring estradiol metabolites over A-ring metabolites may be a risk factor for breast cancer. The present work was aimed to investigate the effect of oral contraceptives (OC) on…

The estradiol metabolism may be of clinical relevance in the pathophysiology of various diseases; the increase in D-ring metabolites over A-ring metabolites in breast cancer patients is of special interest. Since estrogen therapy has been b…

Mueck, A O M.D., Ph.D.; Graeser, T M.D.2; Mellinger, U Ph.D.2; Mueller, A Ph.D.2; Seeger, H Ph.D.1; Oettel, M M.D.2; Lippert, T H M.D.1 Author Information

The effect of estradiol, progesterone, and three progestogens on calcium influx was investigated in cell cultures of human vessels under resting conditions. Estradiol significantly inhibited calcium influx in endothelial and smooth muscle c…