Ruiz A

No ORCID on file · 14 papers in corpus · active 1995-2025

Study types

  • article 9
  • other 2
  • review 1

Condition tags

  • endometriosis 11
  • infertility 4
  • chronic_pelvic_pain 1
other 2025
Revealing the endocrine landscape of INSL3/RXFP2 signaling in hamster
PloS one ·doi:10.1371/journal.pone.0329696

In mammals, insulin-like peptide 3 (INSL3) and its cognate receptor (RXFP2) are reported to be essential regulators of male reproductive physiology. It is also believed that INSL3/RXFP2 signaling has a role in female ovarian function and fo…

article 2017
Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion†
Biology of reproduction ·doi:10.1093/biolre/iox152

High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, reported to be elevated in h…

2016
5th International Symposium on Focused Ultrasound : North Bethesda, MD, USA. 28 August- 1 September 2016
Journal of therapeutic ultrasound
article 2016
Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis
Cell death & disease ·doi:10.1038/cddis.2015.361

In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor …

article 2015
Dysregulation of Lysyl Oxidase Expression in Lesions and Endometrium of Women With Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115585144

UnlabelledLysyl oxidases (LOXs) are enzymes involved in collagen deposition, extracellular membrane remodeling, and invasive/metastatic potential. Previous studies reveal an association of LOXs and endometriosis. We aimed to identify the me…

other 2012
HDAC1 and HDAC2 are differentially expressed in endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719111432870

Epigenetic mechanisms have been ascribed important roles in endometriosis. Covalent histone modifications at lysine residues have been shown to regulate gene expression and thus contribute to pathological states in many diseases. In endomet…

article 2011
Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.06.001

This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like pr…

article 2010
Basal and Steroid Hormone-Regulated Expression of CXCR4 in Human Endometrium and Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719110379920

Endometriosis is associated with activation of local and systemic inflammatory mechanisms, including increased levels of chemokines and other proinflammatory cytokines. We have previously reported increased gene expression of chemokine rece…

article 2009
Patients' report on how endometriosis affects health, work, and daily life
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.09.017

The objective of this study was to assess the burden of endometriosis by obtaining patient-reported outcome data describing the experience of living with this disease. Survey data from 107 women with self-reported, surgically diagnosed endo…

article 2006
Endometrioid adenocarcinoma of the ovary and endometriosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2006.06.008

ObjectiveWe present a retrospective analysis of 22 cases of endometrioid ovarian carcinoma, reviewed to identify endometriosis and its malignant transformation.Study designTwenty-two patients with endometrioid ovarian cancer were included i…

article 2005
Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis
Journal of experimental & clinical assisted reproduction ·doi:10.1186/1743-1050-2-11

BACKGROUND: Endometriosis is a complex disease affecting 10-15% of women at reproductive age. Very few genes are known to be altered in this pathology. RIP140 protein is an important cofactor of oestrogen receptor and many other nuclear rec…

2004
Embryonic chromosomal abnormalities obtained after rescue intracytoplasmic sperm injection of 1-day-old unfertilized oocytes.
Journal of assisted reproduction and genetics ·doi:10.1023/b:jarg.0000025939.26834.93

PurposeTo study if second day intracytoplasmic sperm injection (ICSI) results in chromosomal abnormalities in the embryos.MethodsRescue ICSI was performed on 14 metaphase II (MII) oocytes after unsuccessful conventional IVF, four were ferti…

article 1997
The role of in vitro fertilization and intracytoplasmic sperm injection in couples with unexplained infertility after failed intrauterine insemination
Fertility and Sterility ·doi:10.1016/s0015-0282(97)81497-5

ObjectiveTo determine an optimal insemination technique in patients undergoing IVF after failed IUI and the role of intracytoplasmic sperm injection (ICSI) in such cases.DesignProspective, randomized study in couples with unexplained infert…

review 1995
Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction
Human Reproduction ·doi:10.1093/humrep/10.suppl_2.91

Several retrospective analyses of our in-vitro fertilization (IVF) and oocyte donation programmes have been carried out in an attempt to gain clinical knowledge of the factors implied in the aetiology of endometriosis-associated infertility…