Tokunaga H

No ORCID on file · 9 papers in corpus · active 2008-2021

Study types

  • review 4
  • article 2
  • other 1

Condition tags

  • endometriosis 7
2021
Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125.
Gynecologic oncology reports ·doi:10.1016/j.gore.2021.100847

ObjectiveOvarian cancer (OC) is an intractable gynecological tumor, and frequent recurrence is experienced within a few years even after the complete eradication of tumor tissues by radical resection and neo-adjuvant chemotherapies. The con…

other 2018
Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing
Genes, chromosomes & cancer ·doi:10.1002/gcc.22507

Ovarian clear cell carcinoma (OCCC) is the most refractory subtype of ovarian cancer and more prevalent in Japanese than Caucasians (25% and 5% of all ovarian cancer, respectively). The aim of this study is to discover the genomic alteratio…

article 2018
The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118756751

Endometriotic stromal cells synthesize estradiol via the steroidogenic pathway. Nuclear receptor subfamily 5, group A, member 1 (NR5A1) is critical, but alone not sufficient, in activating this cascade that involves at least 5 genes. To eva…

review 2012
Role of Estrogen Receptor-β in Endometriosis
Seminars in reproductive medicine ·doi:10.1055/s-0031-1299596

Endometriosis is an estrogen-dependent disease. The biologically active estrogen, estradiol, aggravates the pathological processes (e.g., inflammation and growth) and the symptoms (e.g., pain) associated with endometriosis. Abundant quantit…

2011
Traditional Japanese Kampo Medicine: Clinical Research between Modernity and Traditional Medicine-The State of Research and Methodological Suggestions for the Future.
Evidence-based complementary and alternative medicine : eCAM ·doi:10.1093/ecam/neq067

The Japanese traditional herbal medicine, Kampo, has gradually reemerged and 148 different formulations (mainly herbal extracts) can be prescribed within the national health insurance system. The objective of this article is to introduce Ka…

review 2010
17β-Hydroxysteroid Dehydrogenase-2 Deficiency and Progesterone Resistance in Endometriosis
Seminars in reproductive medicine ·doi:10.1055/s-0029-1242992

Estradiol (E2) stimulates the growth and inflammation in the ectopic endometriotic tissue that commonly resides on the pelvic organs. Several clinical and laboratory-based observations are indicative of resistance to progesterone action in …

review 2010
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis
Seminars in reproductive medicine ·doi:10.1055/s-0029-1242991

Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progest…

article 2008
Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2008-1180

CONTEXT: Products of at least five specific steroidogenic genes, including steroidogenic acute regulatory protein (StAR), which facilitates the entry of cytosolic cholesterol into the mitochondrion, side chain cleavage P450 enzyme, 3beta-hy…

review 2008
Steroidogenic factor-1 and endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.12.012

Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertility. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes includ…