Hua Duan

INTRODUCTION: Adenomyosis is an enigmatic disease with estrogen dependence, and the exact pathogenic mechanisms remain confusing. Limited evidence points out the presence of gut flora changes in adenomyosis. However, evidence on how adenomy…

BACKGROUND: Endometriosis is a common gynecological disorder, with rising incidence rates and a decreasing age of onset, significantly affecting patients' quality of life and overall health. Urinary tract endometriosis (UTE) is a rare and i…

BACKGROUND: Peritoneal malignancies (PM) represent a group of highly heterogeneous tumors associated with poor prognosis and limited effective treatment options. Recent studies have demonstrated significant progress in understanding the tum…

Adenomyosis, an estrogen-dependent disorder, requires long-term therapy as current treatments (GnRH agonists, danazol, etc.) show symptom recurrence post-discontinuation. Dienogest (DNG), a selective progesterone receptor agonist, effective…

Adenomyosis (ADS) is a common gynecological disorder, and its pathogenesis remains unclear. This study explores the functions of circRNAs in the eutopic endometrium of ADS and their diagnostic efficacy for ADS. High-throughput RNA sequencin…

OBJECTIVE: To assess the efficacy and safety of Sanjie Analgesic Capsule (SAC) in Chinese patients with endometriosis-associated pain. METHODS: This was a multicenter, randomized, double-blind, placebo-controlled trial conducted at 15 cent…

INTRODUCTION: The endometrial microbiota plays an essential role in the health of the female reproductive system. However, the interactions between the microbes in the endometrium and their effects on adenomyosis remain obscure. MATERIALS …

In the past decade, research on ultrasound therapy in obstetrics and gynecology has rapidly developed. Currently, high-intensity ultrasound has been widely used in clinical practice, while low-intensity ultrasound has gradually emerged as a…

Adenomyosis (ADS) is a common benign gynecological disease. Abnormal proliferation at the endometrial-myometrial interface (EMI) plays a crucial role in the occurrence and progression of ADS. miR-141-3p is associated with cell proliferation…

BACKGROUND: Hysteroscopic metroplasty of the uterine septum has been the standard treatment strategy to improve reproductive outcomes, but there are still controversies about the appropriateness of metroplasty. In addition, there have been …

The junctional zone (JZ) is an important structure in the myometrium that maintains uterine fertility. Changes in the junctional zone are closely related to infertility and adenomyosis (ADS). As an increasing number of young women are affec…

PURPOSE: The study aims to evaluate whether frozen embryo transfer can restore optimal receptivity leading to better assisted reproductive technology outcomes in women with endometriosis. METHODS: This systematic review and meta-analysis, …

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a known regulator of the development and maintenance of chronic pain in various chronic disorders. Together with its high-affinity tyrosine kinase type B (TrKB) receptor, BDNF is exten…

BACKGROUND: After treatment of intrauterine adhesions, the rate of re-adhesion is high and the pregnancy outcome unpredictable and unsatisfactory. This study established and verified a decision tree predictive model of live birth in patient…

BACKGROUND: A comprehensive clinical strategy for infertility involves treatment and, more importantly, post-treatment evaluation. As a component of assessment, endometrial receptivity does not have a validated tool. This study was anchored…

BACKGROUND: A receptive endometrium is a prerequisite for successful embryo implantation. Mounting evidence shows that nearly one-third of infertility and implantation failures are caused by defective endometrial receptivity. This study poo…

BACKGROUND: Uterine adenomyosis is associated with chronic pelvic pain, abnormal uterine bleeding, and infertility. The pathogenesis of adenomyosis is still unclear. Circular RNAs (circRNAs) have been implicated in several benign diseases a…

Additional file 1: Supplementary Figure S1. Morphological features of adenomyotic eutopic and ectopic endometrial stromal cells. A.and B. The primary culture of ADS_Eu_ESC and ADS_Ec_ESC cells to the fourth day, respectively. C. The third g…

Additional file 1: Supplementary Figure S1. Morphological features of adenomyotic eutopic and ectopic endometrial stromal cells. A.and B. The primary culture of ADS_Eu_ESC and ADS_Ec_ESC cells to the fourth day, respectively. C. The third g…

Several theories on the origin of adenomyosis (ADS) have been proposed, of which the most widely accepted is the fundamental pathogenic role of uterine eutopic endometrium. Emerging evidence suggests that circular RNAs participate in the mu…

The estrogen 17β‑estradiol has been proven to serve an indispensable role in the occurrence and development of adenomyosis (ADS). The let‑7a/Lin28B axis can control cell proliferation by acting as a tumor‑inhibiting axis in numerous types o…

Abstract Background: Brain-derived neurotrophic factor (BDNF) has been recognized as a regulator in the formation and maintenance of chronic pain in various chronic disorders. BDNF together with its high-affinity tyrosine kinase type B (Trk…

Abstract Background: Brain-derived neurotrophic factor (BDNF) has been recognized as a regulator in the formation and maintenance of chronic pain in various chronic disorders. BDNF together with its high-affinity tyrosine kinase type B (Trk…

RESEARCH QUESTION: Does ferroptosis resistance occur in patients with endometriosis, and can it be used as an indicator for diagnosis? DESIGN: Six datasets including 164 expression arrays from endometriosis studies were selected from the N…