Xu H

This study aims to explore the application value of stromal cell-derived factor (CXCL12), vascular endothelial growth factor (VEGF) and carbohydrate antigen 125 (CA125) in the diagnosis, staging, and clinical manifestations of endometriosis…

BACKGROUND: Insulin resistance (IR) is a key metabolic disturbance that adversely affects assisted reproductive technology (ART) outcomes. In women with polycystic ovary syndrome (PCOS), IR has been well documented to impair oocyte quality,…

Endometriosis is a chronic, estrogen-dependent gynecologic disorder characterized by the ectopic growth of endometrial tissue outside the uterus. Zinc finger protein 143 (ZNF143) is a DNA-binding transcription factor, yet its role in endome…

BACKGROUND: Impaired decidualization is a major cause of infertility in patients with adenomyosis (AM). However, the effect of transcription factor 21 (TCF21) on AM and the underlying mechanism of associated-impaired decidualization remain …

OBJECTIVE: To report a rare case of a patient with unicornuate uterus, whose rudimentary horn has finally developed into diffuse adenomyosis foci, and to demonstrate a fertility-preserved approach for the treatment of such a condition. DES…

Following the initial treatment of nasopharyngeal carcinoma (NPC), tumor progression often portends an adverse prognosis for these patients. MicroRNAs (miRNAs) have emerged as critical regulators of tumor immunity, yet their intricate mecha…

OBJECTIVES: This meta-analysis seeks to clarify the relationship between hysterectomy, oophorectomy, and the subsequent risk of developing breast cancer. METHODS: A comprehensive literature search was conducted across PubMed, the Cochrane …

UNLABELLED: Primary dysmenorrhea (PDM) is a common cyclic menstrual pain that significantly affects the quality of life for women. Several epidemiological studies have suggested a potential association between PDM and mental health traits, …

BACKGROUND: The atypical hemolytic uremic syndrome (aHUS) presents diagnostic and therapeutic challenges due to overlapping features with other conditions like Preeclampsia/HELLP syndrome and thrombotic thrombocytopenic purpura (TTP). Pregn…

OBJECTIVE: To assess the efficacy of Cai's Gynecology Chronic Pelvic Formula combined with acupuncture in managing chronic pelvic pain (CPP) secondary to pelvic inflammatory disease (PID) sequelae, and its effect on recurrence. METHODS: A …

BACKGROUND: Preimplantation embryos in vivo are exposed to various growth factors in the female reproductive tract that are absent in in vitro embryo culture media. Cell-free fat extract exerts antioxidant, anti-ageing, and ovarian function…

Intracerebral hemorrhage (ICH) is a most serious type of hemorrhagic stroke with a continuously rising incidence globally, without effective cure available. The underlying mechanisms driving brain injury are complex and include inflammation…

BACKGROUND: Combined oral contraceptives (COCs) can relieve dysmenorrhea, but utilization is low in Chinese women. This systematic literature review was conducted to summarize the design of clinical studies and the effectiveness and safety …

[This corrects the article DOI: 10.3389/fimmu.2021.641206.].

BACKGROUND: Deep infiltrating endometriosis is a subtype of endometriosis. A case of retroperitoneal endometriosis surrounding the ureter and forming a pelvic mass is relatively rare. CASE PRESENTATION: A 26-year-old woman was admitted to …

OBJECTIVE: This study aims to develop a machine learning-based predictive model for patients with endometriosis, with the goal of precisely identifying key factors and reliable predictive markers that influence live birth outcomes following…

In clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (ClinS…

INTRODUCTION: Thin endometrium poses a major therapeutic challenge in assisted reproductive technologies by compromising pregnancy success and live birth outcomes. A substantial proportion of patients remain refractory to existing therapies…

BACKGROUND: This study aimed to observe the effect of dexmedetomidine on the median effective concentration (EC50) of ropivacaine for postoperative analgesia in ultrasound-guided transversus abdominis plane block. METHODS: Patients undergo…

BACKGROUND: This phase 2 trial comprised dose exploration (stage 1) and dose confirmation stages (stage 2) to determine the safety and efficacy of HSK21542 in patients undergoing laparoscopic abdominal surgery. METHODS: In stage 1, patient…

BACKGROUND: Oxidative stress (OS) is a significant challenge in the in vitro embryo culture of patients of advanced age. The Erzhi Tiangui (EZTG) formula has been shown to alleviate OS-induced apoptosis in granulosa cells (GCs) of patients …

INTRODUCTION AND HYPOTHESIS: The objective was to investigate the expressions and significance of IGF-1, pAKT, pS6, and type I and type III collagens in uterosacral ligaments of patients with pelvic organ prolapse (POP). METHODS: A total o…

OBJECTIVE: To study the correlation between anti-Müllerian hormone levels and pregnancy outcomes after in vitro fertilization/intracytoplasmic sperm injection in women with polycystic ovary syndrome, which remains controversial. METHODS: T…

BACKGROUND: Oxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, …