Chow C

No ORCID on file · 12 papers in corpus · active 2003-2022

Study types

  • article 3
  • other 2

Condition tags

  • endometriosis 5
2022
The proteome of clear cell ovarian carcinoma.
The Journal of Pathology ·doi:10.1002/path.6006

Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late-stage CCOC is not responsive to gold-standard chemotherapy and results in suboptimal outcomes for patients. In-depth molecular insig…

2021
STING pathway expression in low-grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?
The journal of pathology. Clinical research ·doi:10.1002/cjp2.230

Ovarian carcinoma histotypes are distinct diseases with variable clinical outcomes and response to treatment. There is a need for new subtype-specific treatment modalities, especially for women with widespread and chemo-resistant disease. S…

2020
Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium.
British journal of cancer ·doi:10.1038/s41416-020-0900-0

BackgroundPTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression as a biomarker …

other 2018
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study
The journal of pathology. Clinical research ·doi:10.1002/cjp2.109

We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemi…

2016
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
The Journal of Pathology ·doi:10.1002/path.4633

Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour inactivating mutations in the …

2015
Morphologic and Molecular Characteristics of Mixed Epithelial Ovarian Cancers.
The American journal of surgical pathology ·doi:10.1097/pas.0000000000000476

Epithelial ovarian cancer (EOC) consists of 5 major histotypes: high-grade serous carcinoma (HGSC), endometrioid carcinoma (EC), clear cell carcinoma (CCC), mucinous carcinoma (MC), and low-grade serous carcinoma (LGSC). Each can have a bro…

2013
Biomarker-based ovarian carcinoma typing: a histologic investigation in the ovarian tumor tissue analysis consortium.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·doi:10.1158/1055-9965.epi-13-0391

BackgroundOvarian carcinoma is composed of five major histologic types, which associate with outcome and predict therapeutic response. Our aim was to evaluate histologic type assessments across the centers participating in the Ovarian Tumor…

2013
Type-specific cell line models for type-specific ovarian cancer research.
PloS one ·doi:10.1371/journal.pone.0072162

BackgroundOVARIAN CARCINOMAS CONSIST OF AT LEAST FIVE DISTINCT DISEASES: high-grade serous, low-grade serous, clear cell, endometrioid, and mucinous. Biomarker and molecular characterization may represent a more biologically relevant basis …

other 2011
Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas
The Journal of Pathology ·doi:10.1002/path.2911

Mutation of the ARID1A gene and loss of the corresponding protein BAF250a has recently been described as a frequent event in clear cell and endometrioid carcinomas of the ovary. To determine whether BAF250a loss is common in other malignanc…

article 2010
ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
The New England journal of medicine ·doi:10.1056/nejmoa1008433

BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-ce…

article 2003
Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(03)00155-9

ObjectiveTo evaluate the utility of fat-suppressed magnetic resonance imaging (MRI) in the diagnosis of endometriosis.DesignA prospective clinical trial.SettingA government research hospital.Patient(s)Forty-eight women with pelvic pain.Inte…

article 2003
Endometriosis arising during estrogen and testosterone treatment 17 years after abdominal hysterectomy: a case report
Maturitas ·doi:10.1016/s0378-5122(03)00081-1

ObjectiveTo report the possible association between the use of oestrogen replacement therapy and endometriosis in a postmenopausal woman.MethodsWe present a case of a postmenopausal, previously hysterectomised, woman who received hormonal r…