Cynthia Dela Cruz

The limitations of current imaging methods to detect small or superficial endometriotic lesions prompt the search for new molecular targets. TSPO is an 18 KDa protein located in the outer mitochondrial membrane, which can be traced by posit…

Background: Inhibins and their co-receptor betaglycan are members of the transforming growth factor β superfamily, a group of signaling molecules that control the differentiation of human endometrium in the secretory phase of the menstrual …

Abstract Study question Is TSPO expressed in endometriotic lesions and negative in adjacent tissues, being eligible as a molecular target for noninvasive detection of endometriosis? Summary answer TSPO is detected in endometriotic lesions a…

Background:Nodal is a growth factor of the transforming growth factor b superfamily that is expressed in high turnover tissues, such as the human endometrium, and in several malignancies. The effects of Nodal are modulated by the coreceptor…

The transforming growth factor-beta (TGFβ) superfamily comprises over 30 dimeric proteins with conserved structures, which play important roles in the control of cellular proliferation, differentiation and apoptosis. These proteins are expr…

No presente estudo, investigamos o papel do Nodal, membro da familia TGF-beta, e de proteinas relacionadas ao seu mecanismo de transducao de sinal, em celulas endometriais estromais estimuladas ou nao, com Estrogeno (10nM), Progesterona (1M…

Endometriosis is a gynecological disease characterized by endometrial tissue outside the uterine cavity and it is associated with pelvic pain and infertility. Members of the TGF-beta family initiate their actions through activation of type …

Endometriosis is a chronic benign disease characterized by the presence of abnormally located tissue resembling the endometrium with glands and stroma. This disease has a high degree of morbidity due to chronic pelvic pain and infertility. …