Reedik Mägi

No ORCID on file · 9 papers in corpus · active 2017-2025

Study types

  • meta-analysis 3
  • other 3
  • article 2

Condition tags

  • endometriosis 7
  • infertility 4
  • irritable_bowel_syndrome 1
meta-analysis 2025
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth
Human Reproduction ·doi:10.1093/humrep/deaf025

STUDY QUESTION: Can a large-scale genome-wide association study (GWAS) meta-analysis identify genomic risk loci and likely involved genes for female genital tract (FGT) polyps, provide insights into the biological mechanism underlying their…

meta-analysis 2025
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum
Nature genetics ·doi:10.1038/s41588-025-02156-8

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female i…

other 2024
Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum
medRxiv : the preprint server for health sciences ·doi:10.1101/2024.03.19.24304530

Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 6…

other 2023
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
Nature human behaviour ·doi:10.1038/s41562-023-01528-6

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci a…

meta-analysis 2023
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Nature genetics ·doi:10.1038/s41588-023-01323-z

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

article 2022
Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities
Human Reproduction ·doi:10.1093/humrep/deac140

STUDY QUESTION: Do the spectrum and prevalence of comorbidities of endometriosis and irritable bowel syndrome (IBS) overlap? SUMMARY ANSWER: Despite several overlapping symptoms, the most significantly associated comorbidities of endometri…

2018
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
·doi:10.1101/245506
other 2017
DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase
Scientific reports ·doi:10.1038/s41598-017-03682-0

The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although not much is known about the endometrial methylome changes …

article 2017
Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis.

Around 50% of endometriosis risk is due to genetic factors. Ten genome-wide significant loci have been associated with endometriosis, but most are located in intergenic regions of the genome. To understand how transcriptomic profiles are pe…