Knöfler M

No ORCID on file · 6 papers in corpus · active 2007-2010

Study types

  • article 3
  • review 1

Condition tags

  • endometriosis 3
article 2010
Administration of βHCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2010.01.010

Preliminary studies have shown that systemic beta-human chorionic gonadotrophin (betaHCG) therapy alleviates endometriosis-related chronic pelvic pain. The underlying mechanism, however, is completely unknown. This study has investigated th…

2009
Beta-hCG/LH receptor (b-HCG/LH-R) expression is increased in invasive versus preinvasive breast cancer: implications for breast carcinogenesis?
Journal of cancer research and clinical oncology ·doi:10.1007/s00432-008-0458-3

IntroductionThe role of the b-HCG/LH/LH-R system in breast cancer is conflicting. Whereas some reports suggest a protective effect of b-HCG on breast epithelium, vitro studies implicate a role of b-HCG/LH-R in the development and growth of …

review 2009
Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium
Placenta ·doi:10.1016/j.placenta.2008.10.012

The cytokine tumour necrosis factor alpha (TNF) is a well known member of the TNF superfamily consisting of at least 18 ligands and 29 different receptors involved in numerous cellular processes. TNF signals through two distinct receptors T…

2008
Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling.
Endocrinology ·doi:10.1210/en.2007-1282

Chorionic gonadotropin (CG) is indispensable for human pregnancy because it controls implantation, decidualization, and placental development. However, its particular role in the differentiation process of invasive trophoblasts has not been…

article 2007
Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.02.006

ObjectiveTo investigate alterations in the overall gene expression profile of endometriosis-derived stroma with increasing concentrations of hCG by using the Affymetrix GeneChip U133 Set.DesignIn vitro study.SettingAcademic research institu…

article 2007
Human chorionic gonadotrophin attenuates NF-κB activation and cytokine expression of endometriotic stromal cells
Molecular human reproduction ·doi:10.1093/molehr/gam032

Recently, a clinical study provided evidence that treatment of endometriotic women with human chorionic gonadotrophin (hCG) alleviates disease-related pain and sleeplessness suggesting therapeutic effects of the hormone. Since endometriosis…