Kun Zhang

PURPOSE: This study aimed to construct a simple nomogram model to predict the benign or malignant nature of ovarian masses. METHODS: A total of 794 patients with ovarian masses from two independent medical centers between 2017 and 2024 wer…

目的：分析比较卵巢子宫内膜异位症（ovarian endometriosis，OEMs）与卵巢良性肿瘤（benign ovarian tumor，BOT）和OEMs合并卵巢癌（Ovarian cancer，OC）患者血清及尿液中脂质代谢产物的差异及相关代谢途径，初步探究与OEMs发生及其恶化相关的脂质成分，进一步深入了解EMs的发生发展机制。 方法：选择10名患有OEMs(对照组)、10名患有BOT（BOT组）和10名患有OEMs合并卵巢癌（恶性组）的育龄期妇女的血清及尿液样…

OBJECTIVE: To analyze the correlation between Clinical Features and Perinatal Outcomes in the population of pregnancies with adenomyosis. METHODS: This retrospective study analyzed 413 pregnant women with ultrasonography/MRI-confirmed aden…

BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease of the pancreas marked by inflammation and acinar cell necrosis. Scutellariae Barbata (S. Barbata), a traditional Chinese herb for inflammation, has unclear efficacy for AP. PU…

BACKGROUND: Bisphenol A (BPA), a widespread environmental endocrine disruptor, has raised concerns for its neurotoxic effects, yet its molecular role in stroke remains unclear. METHODS: BPA target genes were retrieved from ChEMBL, DrugBank,…

BACKGROUND: Traumatic separation of the cervix from the body of the uterus is exceedingly rare, particularly as a complication of pelvic fractures. This condition often poses significant diagnostic and therapeutic challenges, especially in …

The sperm DNA fragmentation index (DFI) is a metric used to assess DNA fragmentation within sperm. During in vitro fertilization-embryo transfer (IVF-ET), high sperm DFI can lead to a low fertilization rate, poor embryo development, early m…

Ferroptosis is a novel type of iron-dependent programmed cell death characterised by intracellular iron overload, increased lipid peroxidation and abnormal accumulation of reactive oxygen species.It has been implicated in the progression of…

PURPOSE: To analyze the level of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) in follicle fluid (FF) and granulosa cells (GCs) derived from young patients with low prognosis for in vitro fertilization and…

OBJECTIVE: The purpose of this study was to investigate iron metabolism indices in ovarian endometriosis (OEMs) and to demonstrate the potential clinical implications in the initiation and development of OEMs. METHODS: Three datasets in Ge…

Deubiquitination is a major form of post-translational protein modification involved in the regulation of protein homeostasis and various cellular processes. Deubiquitinating enzymes (DUBs), comprising about five subfamily members, are key …

OBJECTIVE: This study examined the feasibility and safety of allogeneic uterus transplantation (UTx) from a living donor and assessed short-term graft viability in a rhesus model. This research is an important step towards further clinical …

OBJECTIVE: To explore the association between endometriosis stage, characteristics of endometriotic lesions and severity of dysmenorrhoea. METHODS: The clinical data were collected from 140 patients with laparoscopically diagnosed endometr…

Objective To investigate the diagnosis of low field MRI and operation treatment of diffuse adenomyosis. Methods A retrospective analysis of 15 cases of uterine adenomyosis confirmed by operation and pathology. Results MRI showed a diffuse i…