Wang L

BACKGROUND AND OBJECTIVES: Multimorbidity is increasingly prevalent among the middle-aged population, yet it is largely often overlooked. We aimed to explore and compare the differences in multimorbidity patterns by sex and age among middle…

BACKGROUND: Multimorbidity substantially increases health and economic burdens, and reduces productivity in working-age individuals. We conducted a study using data from 393,170 working-age inpatients (18-59 years) in Shaanxi, China, collec…

BACKGROUND: Premature Ovarian Failure (POF) is a heterogeneous syndrome characterized by ovarian dysfunction, frequently associated with autoimmune factors. The interaction between peripheral and ovarian immune signals remains unclear. Rece…

BACKGROUND: Non-small cell lung cancer (NSCLC) ranks first among common cancers worldwide and first among causes of cancer death. This study explored the function of ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) on …

Endometriosis (EMs) is a common gynecological disorder frequently associated with infertility, yet the underlying immune mechanisms remain poorly understood. Sun's Bushen Huayu Formula (BSHYF) has been clinically applied to improve fertilit…

Endometriosis is a chronic, estrogen-dependent disorder influenced by both genetic and environmental factors, including endocrine-disrupting chemicals (EDCs). This study aimed to identify EDC-responsive genes contributing to endometriosis r…

Chronic fatigue syndrome (CFS) is a complex disease involving multiple systems throughout the body with unknown pathogenesis and is characterized by chronic fatigue. To date, no effective treatment for CFS has been found, as well as biomark…

BACKGROUND: Delayed childbearing has become an increasingly prevalent trend, influenced by various psychological and social factors. This study aimed to explore the impact of these factors on the timing of childbirth among women of reproduc…

Fan W, Zhai F, Yuan Z, Hu G, Wang L. Drug Des Devel Ther. 2025;19:2717-2735. Authors have noticed errors in the western blot antibody information stated in the Material and Methods section on page 2718. In the “Materials and Methods-…

Weisen Fan,1 Fengting Zhai,2 Zheng Yuan,2 Guotao Hu,1 Li Wang2 1Department of Gynecology, Guang ‘anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, People’s Republic of China; 2Department of Gynecology, Affiliated H…

INTRODUCTION: In traditional Chinese medicine texts, Xuanyu Tongjing Decoction (XYTJD) is a prescribed remedy for premenstrual belly pain and dysmenorrhea. It is currently routinely used to treat ovarian endometriosis (OEM) with good outcom…

BACKGROUND: Infertility has a significant impact on women, affecting them both mentally and physically. Some of the current infertility-related diseases include intrauterine adhesions, endometriosis, polycystic ovary syndrome, primary ovari…

BACKGROUND: This study aimed to evaluate the clinical outcomes of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on ovarian function in women with premature ovarian insufficiency (POI), and its potential to improve in vitro f…

RATIONALE: Uterine perforation complicated by incarcerated fallopian tube and cesarean scar pregnancy (CSP) constitutes an exceptionally rare and clinically challenging condition. The diagnostic dilemma arises from elevated β-hCG levels com…

OBJECTIVE: To evaluate the association of adenomyosis subtypes defined by ultrasound using the revised Morphological Uterus Sonographic Assessment (MUSA) criteria, with reproductive and obstetric outcomes following frozen embryo transfer (F…

Endometriosis and Recurrent Implantation Failure (RIF) are both pivotal clinical issues within the realm of reproductive medicine, sharing significant overlap in their pathophysiological mechanisms. However, research exploring the commonali…

BACKGROUND: While endometriosis (EM) has been previously associated with multiple immune factors, the causal relationship underlying these associations remains unclear. OBJECTIVE: In this study, Two-sample Mendelian randomization (MR) meth…

Jie Mei,1– 3,* Xi-Ya Jiang,1,2,* Bin Zhang,4,* Li Wang,5 Ai-Xi Zhang,6 Jie-Jie Li,1– 3 Shun-Xia Chen,1,2 Xiao Xu,1,2 Jing‑Jing Hu,7 Shu-Guang Zhou1– 3 1Department of Gynecology, The Fifth Affiliated Clinical College of Anhui Medical Univers…

Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well as endocrine abnormalities and immune disorders. This review discusses the mechanisms underlying end…

OBJECTIVE: Explored the risk factors for venous thromboembolism in gynecological inpatients in western China, and developed an improved model to predict the VTE of this patient population. METHODS: The records of 6897 patients hospitalized…

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as a pivotal enzyme in androgen biosynthesis. It catalyzes the conversion of weak…

BACKGROUND AND AIMS: Intrahepatic cholestasis of pregnancy (ICP) is a special liver disease during pregnancy, characterized by abnormal bile acid metabolism. However, there is no consensus on how to group women with ICP based on the time of…

Endometriosis (EM), also known as Zhengjia in traditional Chinese medicine, is a common disease that significantly impacts women's health. An integrated treatment approach combining traditional Chinese medicine (TCM) and western medicine ha…

BACKGROUND: The imbalance between the generation and elimination of reactive oxygen species (ROS) is defined as oxidative stress (OS). Elevated levels of OS are implicated in various diseases, especially in gynecological and reproductive di…