A systematic review of the mechanistic actions of microRNAs within integrated traditional Chinese medicine and western medical treatment for endometriosis

Lisha Li, Yiqin Zhang, Jing Zhou, Jing Wang, Ling Wang
Drug discoveries & therapeutics · 2024 · vol. 18(1) , pp. 1–9 · doi:10.5582/ddt.2024.01004 · PMID:38417896
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This review summarizes how microRNAs might mediate the therapeutic effects of integrated traditional Chinese and Western medicine for endometriosis by modulating ectopic lesion growth and symptoms.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This 2024 systematic review summarizes mechanistic evidence on how microRNAs might mediate therapeutic effects of integrated traditional Chinese medicine and western medicine in endometriosis. It focuses on research suggesting that combined treatment influences microRNA expression, which could in turn inhibit the growth of ectopic lesions and alleviate clinical symptoms. The paper consolidates reported miRNAs and discusses their proposed mechanisms of action, with the stated goal of clarifying the integrated approach’s therapeutic benefits and identifying directions for further study. This paper is centrally about endometriosis — it specifically reviews microRNA mechanisms linking integrated TCM and western medical treatment to endometriosis-related lesion growth and symptoms.

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Abstract

Endometriosis (EM), also known as Zhengjia in traditional Chinese medicine, is a common disease that significantly impacts women's health. An integrated treatment approach combining traditional Chinese medicine (TCM) and western medicine has demonstrated significant clinical efficacy in the management of this condition. Specifically, it has been effective in addressing blood circulation and other diseases. MicroRNAs (miRNAs), which are molecules important in gene regulation, have been implicated in various physiologic and pathologic processes. In this review, we systematically summarized the potential mechanisms underlying the integrated EM treatment, with a focus on the role of microRNAs (miRNAs). Current research suggests that integrated TCM and western medicine treatment may exert their therapeutic effects on EM by influencing the expression of miRNAs. Through miRNA modulation, such a treatment approach may inhibit the growth of ectopic lesions and alleviate clinical symptoms. This review will shed light on the specific miRNAs that have been implicated in the integrated treatment of EM, as well as their potential mechanisms of action. By consolidating the existing evidence, we aim to provide clinicians and researchers with a clearer understanding of the therapeutic benefits of the integrated approach and potentially identify new avenues for improving clinical treatment outcomes. Ultimately, this review will contribute to the growing body of knowledge in this field, providing a basis for further research and the development of more targeted and efficient treatment strategies for EM.
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Review A systematic review of the mechanistic actions of microRNAs within integrated traditional Chinese medicine and western medical treatment for endometriosis 2024 Volume 18 Issue 1 Pages 1-9 Details Abstract Endometriosis (EM), also known as Zhengjia in traditional Chinese medicine, is a common disease that significantly impacts women's health. An integrated treatment approach combining traditional Chinese medicine (TCM) and western medicine has demonstrated significant clinical efficacy in the management of this condition. Specifically, it has been effective in addressing blood circulation and other diseases. MicroRNAs (miRNAs), which are molecules important in gene regulation, have been implicated in various physiologic and pathologic processes. In this review, we systematically summarized the potential mechanisms underlying the integrated EM treatment, with a focus on the role of microRNAs (miRNAs). Current research suggests that integrated TCM and western medicine treatment may exert their therapeutic effects on EM by influencing the expression of miRNAs. Through miRNA modulation, such a treatment approach may inhibit the growth of ectopic lesions and alleviate clinical symptoms. This review will shed light on the specific miRNAs that have been implicated in the integrated treatment of EM, as well as their potential mechanisms of action. By consolidating the existing evidence, we aim to provide clinicians and researchers with a clearer understanding of the therapeutic benefits of the integrated approach and potentially identify new avenues for improving clinical treatment outcomes. Ultimately, this review will contribute to the growing body of knowledge in this field, providing a basis for further research and the development of more targeted and efficient treatment strategies for EM. © 2024 International Research and Cooperation Association for Bio & Socio-Sciences Advancement Favorites & Alerts Recently viewed articles

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endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Medicine, Chinese Traditional Medicine, Chinese Traditional Medicine, Chinese Traditional Medicine, Chinese Traditional Medicine, Chinese Traditional Medicine, Chinese Traditional Medicine, Chinese Traditional MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs

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