Paragi G

No ORCID on file · 2 papers in corpus · active 2021-2026
2026
Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand
Cancers
2021
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives.
Journal of enzyme inhibition and medicinal chemistry ·doi:10.1080/14756366.2021.1937142

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. T…