Chen W

PURPOSE: To investigate BMAL1 and BMP6 expressive differences in ovarian granulosa cells (OGCs) of patients with polycystic ovary syndrome (PCOS), explore regulatory relationship, assess their impacts on OGC proliferation and apoptosis, and…

Endometriosis is a complex, chronic inflammatory gynecological disorder with estrogen‑dependent characteristics that severely impairs the quality of life of women and potentially leads to infertility. However, its pathogenesis remains poorl…

Thoracic endometriosis syndrome is a rare form of endometriosis in which endometrial tissue is thought to migrate to the lungs and, with the onset of menstruation, the ectopic foci bleed, causing a range of pulmonary manifestations. In this…

OBJECTIVE: To investigate the efficacy of the Er Zhi Tian Gui Formula (EZTGF) in diminished ovarian reserve (DOR) patients undergoing in vitro fertilization-embryo transfer (IVF-ET); to examine the pharmacological mechanism of EZTGF in inhi…

OBJECTIVES: The aim of this study was to assess the clinical outcomes of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA) of different sizes. MATERIALS AND METHODS: A total of 88 pat…

PURPOSE: This study aimed to compare the efficacy of human chorionic gonadotropin (hCG) and dual-trigger (gonadotropin-releasing hormone agonist [GnRH-a] and hCG) protocols in terms of cumulative live birth rate (CLBR) and other pregnancy o…

OBJECTIVE: To investigate the different characteristics and maternal-neonatal outcomes of twin and singleton pregnancies complicated by placenta accrete spectrum (PAS). METHODS: A retrospective analysis was conducted on 783 singleton and 10…

Antibodies have been widely used globally over the past decade and play an increasingly important role in modern medicine. Notably, significant advancements have been achieved in the realm of gynecology, particularly in gynecological cancer…

Ovarian cancer(OC) poses a significant clinical challenge due to its frequent peritoneal dissemination and development of chemotherapy resistance, contributing to poor patient outcomes. Chronic inflammation is a pivotal driver of disease in…

INTRODUCTION AND HYPOTHESIS: We aimed to develop and validate a clinically applicable risk assessment model for identifying women at a high risk of pelvic organ prolapse (POP) based on a retrospective practice. METHODS: This study enrolled…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by symptoms such as hyperandrogenemia, oligo or anovulation and polycystic ovarian, significantly impacting…

RESEARCH QUESTION: Does frozen embryo transfer improve pregnancy outcomes compared with fresh embryo transfer in women with ovarian endometriosis (OEM) undergoing their first IVF/intracytoplasmic sperm injection cycle? DESIGN: A retrospect…

OBJECTIVES: Whether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes. DESIGN: A retrospective cohort study. SETTING: Wenzhou, Zhengjiang Province, Ch…

BACKGROUND: Total fertilization failure (TFF) or near TFF may lead to cycle cancellation, which is a highly frustrating experience for patients, especially those who have undergone multiple attempts. Early rescue intracytoplasmic sperm inje…

Endometriosis (EMs) is a common inflammatory disorder in women of reproductive age, severely impacting patients' quality of life and fertility. Current hormonal therapies offer limited efficacy, and surgical interventions often fail to prev…

The skeletal muscle is highly susceptible to injury in daily life. Severe skeletal muscle injuries often result in incomplete regeneration, leading to functional impairment. In clinical practice, understanding the extent of skeletal muscle …

BACKGROUND: The incidence of endometriosis is rising, particularly among younger populations, yet current diagnostic and therapeutic approaches remain limited. This highlights the urgent need for novel diagnostic tools and effective treatme…

OBJECTIVE: This prospective study aimed to investigate the short-term effects of single-port laparoscopic hysterectomy for benign conditions on postoperative pelvic floor symptoms, pelvic floor structure, and pelvic floor muscle function. …

PURPOSE: Emerging evidence suggests that an abnormal endometrial microbiota may be a potential factor contributing to recurrent pregnancy loss (RPL). This study aimed to characterize the endometrial microbiota in patients with RPL and to ex…

Long non-coding RNAs (lncRNAs) affect the biological functions of granulosa cells (GCs) through multiple mechanisms, including epigenetic regulation, transcriptional regulation, post-translational modification, and cell signaling. Our previ…

OBJECTIVE: Ovarian cancer (OC) is a common malignant tumor in women, with poor prognosis and high mortality rates. Early diagnosis, screening, and prognostic prediction of OC have long been focal points and challenges in this field. In rece…

BACKGROUND: To assess the utility of the TCGA molecular classification of endometrial cancer in a well-annotated, moderately sized, consecutive cohort of Chinese patients with ovarian clear cell carcinoma (OCCC). METHODS: We performed DNA …

Polycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here,…

PURPOSE: The study aimed to develop a nomogram to predict live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment. MATERIALS AND METHODS: Data were collected from the Center for Reproductive Medicine, Shandong…

BACKGROUND: Poor ovarian response (POR) is a pathological condition characterized by inadequate ovarian response to gonadotropin stimulation in patients undergoing in vitro fertilization and embryo transfer. It represents a primary cause of…