Lois A. Salamonsen

BackgroundAlthough endometriosis is a common cause of pelvic pain and infertility, the pathogenesis of the disease remains poorly understood. Several theories have been proposed to explain the mechanisms involved in the development of this …

Background Although endometriosis is a common cause of pelvic pain and infertility, the pathogenesis of the disease remains poorly understood. Several theories have been proposed to explain the mechanisms involved in the development of this…

Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…

Endometriosis is a chronic disorder affecting approximately 10% of women in whom endometrial tissue forms painful lesions outside the uterus. It has a major impact on their physical, mental and social well-being but has no known cure, and t…

Over the past decade, high-throughput proteomics technologies have evolved considerably and have become increasingly more commonly applied to the investigation of female reproductive diseases. Proteomic approaches facilitate the identificat…

“The Curse,” the “Period,” “Riding the Crimson Wave,” “Aunt Flo,” and “the Red Coats are Coming” (euphemisms for menstrual bleeding) capture the long history of taboo and mystery of menstruation, a critical component of reproductive capabil…

Hormonal contraceptives are unsuitable for many women; thus, the development of new, nonhormonal contraceptives is of great interest. In women, uterine epithelial expression of interleukin 11 (IL11) and its receptor (IL11RA) suggests IL11 i…

Endometriosis is an estrogen-dependent disorder where endometrial tissue forms lesions outside the uterus. Endometriosis affects an estimated 10% of women in the reproductive-age group, rising to 30% to 50% in patients with infertility and/…

Embryo implantation involves blastocyst attachment to the endometrial luminal epithelium, followed by trophoblast invasion. This process involves a coordinated crosstalk between the implanting blastocyst and the endometrium. Adhesion molecu…

Knowledge of the molecular mechanisms underlying menstruation and menstrual disorders is limited. We propose that menstrual disorders are a result of incorrect or inadequate endometrial restoration/healing after menses, and that this is lik…

Read the full review for this Faculty Opinions recommended article: beta-HCG/LH receptor (beta-HCG/LH-R) expression in eutopic endometrium and endometriotic implants: evidence for beta-HCG sensitivity of endometriosis.

BACKGROUND: Abnormal bleeding is common in hormone therapy (HT) users. We aimed to determine how HT alters endometrial blood vessels and stromal factors known to regulate vascular growth and integrity. METHODS: Prospective observational st…

The current dogma surrounding endometrial regeneration after menses includes a critical need for estrogen-primed proliferation. Although some evidence suggests that estrogen may not be required for the initial reepithelialization of the ute…

BACKGROUND: Uterine receptivity and embryo implantation are critical in the establishment of pregnancy. The diagnosis of endometrial fertility requires more precise measurements of endometrial receptivity. Interleukin (IL-11) and leukemia i…

BACKGROUND: Understanding the pathophysiology of chemokine secretion in endometriosis may offer a novel area of therapeutic intervention. This study aimed to identify chemokines differentially expressed in epithelial glands in eutopic endom…

Read the full review for this Faculty Opinions recommended article: Reduced levels of VEGF-A and MMP-2 and MMP-9 activity and increased TNF-alpha in menstrual endometrium and effluent in women with menorrhagia.

CONTEXT: Irregular bleeding is common in users of combined hormone therapy (HT) and often leads to invasive and expensive investigations to exclude underlying pathology. The mechanisms of HT-related bleeding are poorly understood. Endometri…

Interleukin (IL)-11 is essential for embryo implantation in the mouse and evidence suggests it has a role in implantation in humans. This study has evaluated immunoreactive IL-11, IL-11 receptor (R) alpha and leukemia inhibitory factor (LIF…

Considerable correlative evidence suggests an important role for matrix metalloproteinases (MMPs) in menstruation, a process which occurs naturally in very few species. In this study, MMP expression was examined in a mouse model of endometr…

Endometriosis is an inflammatory condition with elevated leukocyte infiltrate; defined as the ectopic growth of endometrium-like tissue, characterised by epithelial glands, outside the uterus. Chemokines selectively regulate influx and acti…