Qionghua Chen

BACKGROUND: Ovarian endometriosis (OEMs) is a primary cause of female infertility and is driven primarily by fibrosis, which disrupts the ovarian follicular microenvironment. Pirfenidone (PFD), an FDA-approved antifibrotic drug, holds promi…

Endometriosis (EM) is a chronic, estrogen-dependent disease characterized by the ectopic presence of endometrial-like tissue. Despite extensive research, its molecular pathogenesis remains unclear. In this study, we conducted an integrated …

BACKGROUND: Recurrent implantation failure (RIF) remains a significant barrier in assisted reproductive technology (ART), where multiple transfers of high-quality embryos fail to achieve pregnancy. While embryo-related factors have been ext…

PURPOSE: Endometriosis is characterized by the ectopic growth of endometrial-like tissue outside the uterus and altered energy metabolism, but the specific mechanisms involved remain unclear. This study aimed to investigate the impact of Si…

Additional file 10. Detailed Kub-sites of 41 key proteins in the fibrosis-related pathway of endometriosis (Table S9)

Additional file 10. Detailed Kub-sites of 41 key proteins in the fibrosis-related pathway of endometriosis (Table S9)

Additional file 1. Fig. S1 Functional enrichment analysis of transcriptomic data in endometriosis. Fig. S2 Functional enrichment analysis of proteomics data in endometriosis. Fig. S3 Functional enrichment analysis of different types of DEPs…

Additional file 1. Fig. S1 Functional enrichment analysis of transcriptomic data in endometriosis. Fig. S2 Functional enrichment analysis of proteomics data in endometriosis. Fig. S3 Functional enrichment analysis of different types of DEPs…

Additional file 2. Clinical information for the sequencing and validation cohorts (Table S1)

Additional file 2. Clinical information for the sequencing and validation cohorts (Table S1)

Additional file 3. Enriched results of GO and KEGG analysis for DEGs in transcriptomics (Table S2)

Additional file 3. Enriched results of GO and KEGG analysis for DEGs in transcriptomics (Table S2)

Additional file 4. Enriched results of GO and KEGG analysis for DEPs in proteomics (Table S3)

Additional file 4. Enriched results of GO and KEGG analysis for DEPs in proteomics (Table S3)

Additional file 5. Integrated transcriptome and proteome analysis results (Table S4)

Additional file 5. Integrated transcriptome and proteome analysis results (Table S4)

Additional file 6. A list of ubiquitination-related regulatory enzymes identified by proteomics (Table S5)

Additional file 6. A list of ubiquitination-related regulatory enzymes identified by proteomics (Table S5)

Additional file 7. Enriched results of GO and KEGG analysis for DUPs in ubiquitylomics (Table S6)

Additional file 7. Enriched results of GO and KEGG analysis for DUPs in ubiquitylomics (Table S6)

Additional file 8. Integration of ubiquitylome, proteome, and transcriptome data (Table S7)

Additional file 8. Integration of ubiquitylome, proteome, and transcriptome data (Table S7)

Additional file 9. Results from integrated analysis of three omics datasets for 518 fibrosis-related proteins (Table S8)

Additional file 9. Results from integrated analysis of three omics datasets for 518 fibrosis-related proteins (Table S8)

Endometriosis (EMs)-related infertility commonly has decreased endometrial receptivity and normal decidualization is the basis for establishing and maintaining endometrial receptivity. However, the potential molecular regulatory mechanisms …