Zhang C

Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report that transcript…

Infertility is a complex and sensitive phenomenon experienced by many couples worldwide. Our study investigated the causal effects of 486 serum metabolites on infertility using a Mendelian randomization (MR) approach, providing insights int…

The female immune system operates within an evolutionary stability-plasticity trade-off, where the physiological demands of pregnancy necessitate a considerable degree of regulatory T cell (Treg) plasticity. This essential flexibility, howe…

INTRODUCTION: Hydrosalpinx is one of the common organic causes of infertility, and the accumulation of fluid in this condition can severely affect embryo implantation and development. MATERIAL AND METHODS: We collected fallopian tube fluid…

BACKGROUND: Uterine cystic adenomyosis is a rare form of focal adenomyosis that is primarily located within the myometrium. In this case report, we present a unique case of adult uterine cystic adenomyosis found outside the uterus following…

INTRODUCTION: This study aimed to explore the feasibility and safety of robotic single port vaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) hysterectomy when compared with traditional vaginal natural orifice translumina…

BACKGROUND: Copy number variations (CNVs) of uncertain significance (VUS) are increasingly identified through prenatal and postnatal genetic testing, yet their clinical interpretation remains challenging. We report a neonate with hematologi…

OBJECTIVE: To identify if there is a high-risk group for chronic endometritis (CE) in infertile women. METHODS: A retrospective single-center cohort study was conducted on 209 infertile women with CE and 843 women without. Both univariate …

BACKGROUND: The levonorgestrel intrauterine system (LNG-IUS) may have its contraceptive or therapeutic efficacy compromised if displacement or expulsion occurs. By suturing and securing the device to the uterine wall, the risk of expulsion …

BACKGROUND: Carotenoids, known for their antioxidant properties and potential health benefits, have attracted considerable attention. Nonetheless, the association between carotenoid levels and gallstone prevalence has not been adequately ex…

OBJECTIVE: To investigate the clinical features of bladder endometriosis and factors associated with urinary symptoms, pregnancy outcomes, and long-term effects of symptom relief and recurrence. DESIGN: A single-center retrospective cohort…

BACKGROUND: Existing biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker can…

OBJECTIVES: The aim of this study was to assess the clinical outcomes of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA) of different sizes. MATERIALS AND METHODS: A total of 88 pat…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic condition in reproductive-aged women, linked to infertility and long-term cardiometabolic risk. Early identification remains challenging because current diagnosis …

Endometriosis, a complex gynecological disorder characterized by aberrant growth of endometrial tissue outside the uterine cavity, poses a significant challenge to women's health. Emerging evidence implicates environmental pollutants, parti…

Di(2-ethylhexyl) phthalate (DEHP), the most prevalent plasticizer worldwide, can enter the human body via various exposure pathways, including ingestion, inhalation, skin contact, and medical applications. It has been observed to exhibit ch…

BACKGROUND: While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an at…

BACKGROUNDS: The study was designed to analyze early pregnancy loss rates in first-time fresh embryo transfer cycles in low prognosis patients according to the POSEIDON criteria. METHODS: This was a retrospective cohort study, including pa…

BACKGROUND: Ovarian sex cord-stromal tumors (OSCSTs) are a rare and heterogeneous group of ovarian neoplasms, encompassing various subtypes such as ovarian thecoma, fibroma (including cellular fibroma), and ovarian granulosa cell tumors (OG…

BACKGROUND: Accurate early diagnosis of ovarian cancer is crucial. The objective of this research is to create a comprehensive model that merges clinical variables, O-RADS, and deep learning radiomics to support preoperative diagnosis and a…

OBJECTIVE: To explore the micro blood flow characteristics of normal singleton pregnancy placenta in middle and late pregnancy based on microvascular flow (MV-Flow) imaging. METHODS: We conducted a retrospective cohort study. Clinical reco…

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ …

BACKGROUND: Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehens…