Elke Winterhager

The expression of human CYR61 (cysteine-rich, angiogenic inducer, 61; CCN1) mRNA has been previously shown to be deregulated in the endometrium of women with endometriosis. We have chosen the baboon model (Papio anubis) of induced endometri…

BACKGROUND: Connexins comprise a family of ~20 proteins that form intercellular membrane channels (gap junction channels) providing a direct route for metabolites and signalling molecules to pass between cells. This review provides a critic…

6Both authors contributed equally to this study. Gene expression pro®ling was performed to identify genes involved in the development of endometriosis. In the secretory phase of the menstrual cycle, several estrogen-regulated genes were up-…

The CCN family of proteins consists of six high homologous matricellular proteins which act predominantly by binding to heparin sulphate proteoglycan and a variety of integrins. Interestingly, CCN proteins are regulated by ovarian steroid h…

Endometriosis is considered as an estrogen-dependent disease. These findings are supported by changes in the estrogen receptor α to estrogen receptor β ratio and by a local increase in estrogen synthesis in endometriotic tissues. The enhanc…

Endometriosis was first described by Carl von Rokitansky in 1860, but to date, over 150 years later, endometriosis remains an enigmatic disease. Its pathophysiology, diagnosis and medical treatment continue to challenge basic and medical sc…

Progestins are successfully used in the treatment of endometriosis; however, the exact mechanisms of their action are still unsolved. We here focused on the effect of different progestins on parameters of extracellular matrix degradation an…

The pro-angiogenic factor cysteine-rich protein 61 (CYR61/CCN1) mediates different signals in tumorigenesis, angiogenesis and is involved in the pathogenesis of endometriosis. In this study we investigated the temporal and spatial expressio…

Die Entwicklung effektiver Therapieansätze zur kausalen Behandlung der Endometriose bedarf des Verständnisses ihrer Pathogenese und der pathophysiologischen Mechanismen. Zur Untersuchung dieser stehen neben in vitro Untersuchungen an Zellli…

The expression of human CYR61 (cysteine-rich, angiogenic inducer, 61; CCN1) mRNA has been previously shown to be deregulated in the endometrium of women with endometriosis. We have chosen the baboon model (Papio anubis) of induced endometri…

Endometriosis is a common gynecologic disorder characterized by the presence of endometrial tissue outside the uterus. The disease is associated with dysmenorrhea, pelvic pain and infertility, but the cell biological mechanisms involved in …

Gene expression profiling was performed to identify genes involved in the development of endometriosis. In the secretory phase of the menstrual cycle, several estrogen-regulated genes were up-regulated in endometria of women with endometrio…

Cysteine-rich protein 61 (CYR61/CCN1) is an angiogenic factor and a member of a family of growth factor-inducible immediate-early genes with functions in cell adhesion, proliferation and differentiation. Previously, we have shown that CYR61…

Endometriosis is one of the most frequent diseases in gynecology. It is histologically defined as a non-malignant pathology in which endometrial-like tissue is found outside the uterus. The pathogenesis and mechanisms involved in the develo…