Patel MV

No ORCID on file · 8 papers in corpus · active 2010-2021
2021
Medroxyprogesterone acetate inhibits wound closure of human endometrial epithelial cells and stromal fibroblasts in vitro.
Scientific reports ·doi:10.1038/s41598-021-02681-6

Mucosal integrity in the endometrium is essential for immune protection. Since breaches or injury to the epithelial barrier exposes underlying tissue and is hypothesized to increase infection risk, we determined whether endogenous progester…

2021
Sex Hormones and Aging Modulate Interferon Lambda 1 Production and Signaling by Human Uterine Epithelial Cells and Fibroblasts.
Frontiers in immunology ·doi:10.3389/fimmu.2021.718380

Estradiol (E2) and progesterone (P) have potent effects on immune function in the human uterine endometrium which is essential for creating an environment conducive for successful reproduction. Type III/lambda (λ) interferons (IFN) are impl…

2018
Estradiol-regulated innate antiviral responses of human endometrial stromal fibroblasts.
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13042

ProblemThe contribution of fibroblasts to innate immune protection of the human female reproductive tract (FRT) against viral pathogens is relatively unknown.Method of studyEndometrial (EM), endocervical (Cx) and ectocervical (ECx) fibrobla…

2018
Poly (I:C) and LPS induce distinct immune responses by ovarian stromal fibroblasts.
Journal of Reproductive Immunology ·doi:10.1016/j.jri.2018.05.001

Despite its anatomical location, the ovary is a site of pathogen exposure in the human female reproductive tract (FRT). However, the role of ovarian stromal fibroblasts in immune protection is unclear. We generated a population of ovarian s…

2017
Tenofovir Inhibits Wound Healing of Epithelial Cells and Fibroblasts from the Upper and Lower Human Female Reproductive Tract.
Scientific reports ·doi:10.1038/srep45725

Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV-target cell recruitment. Here we determined whether Tenofovir (TF…

2015
The role of sex hormones in immune protection of the female reproductive tract.
Nature reviews. Immunology ·doi:10.1038/nri3819

Within the human female reproductive tract (FRT), the challenge of protection against sexually transmitted infections (STIs) is coupled with the need to enable successful reproduction. Oestradiol and progesterone, which are secreted during …

2014
Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens.
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12252

The immune system in the female reproductive tract (FRT) does not mount an attack against human immunodeficiency virus (HIV) or other sexually transmitted infections (STI) with a single endogenously produced microbicide or with a single arm…

2010
Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens.
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2010.00842.x

The immune system in the female reproductive tract (FRT) does not mount an attack against HIV or other sexually transmitted infections (STI) with a single endogenously produced microbicide or with a single arm of the immune system. Instead,…