Lalitkumar PGL

No ORCID on file · 7 papers in corpus · active 2018-2024

Study types

  • other 3
  • article 2
  • preprint 1

Condition tags

  • endometriosis 5
  • endometrioma 2
  • chronic_pelvic_pain 1
  • infertility 1
  • adenomyosis 1
other 2024
Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level
Communications biology ·doi:10.1038/s42003-024-06713-5

Current therapeutics of endometriosis focus on hormonal disruption of endometriotic lesions (ectopic endometrium, EcE). Recent findings show higher glycolysis utilization in EcE, suggesting non-hormonal strategy for disease treatment that a…

preprint 2024
Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level
·doi:10.1101/2024.02.27.580606

Abstract Current therapeutics of endometriosis are limited to hormonal action on endometriotic lesions to disrupt their growth. Based on the recent findings of the high utilization of glycolysis over oxidative metabolism (Warburg-like effec…

other 2024
Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis
Frontiers in endocrinology ·doi:10.3389/fendo.2024.1465393

BACKGROUND: Endometriosis is characterized by the ectopic growth of endometrial-like cells, causing chronic pelvic pain, adhesions and impaired fertility in women of reproductive age. Usually, these lesions grow in the peritoneal cavity in …

article 2023
Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1026168

OBJECTIVE: Bromocriptine treatment has been shown to reduce menstrual bleeding and pain in women with adenomyosis in a pilot clinical trial. The underlying mechanism contributing to the treatment effect is however unknown. The purpose of th…

article 2020
Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis
Human Reproduction ·doi:10.1093/humrep/deaa164

STUDY QUESTION: What is the physiological role of transforming growth factor-beta (TGF-β1) and syndecans (SDC1, SDC4) in endometriotic cells in women with endometriosis? SUMMARY ANSWER: We observed an abnormal, pro-invasive phenotype in a s…

2019
Embryonic Aneuploidy after Preimplantation Genetic Screening: Age- and Indication-Matched Comparative Study between Indian and Spanish Population.
Journal of human reproductive sciences ·doi:10.4103/jhrs.jhrs_109_18

BackgroundRecent studies show that there are differences in female fertility in different ethnic groups with ovarian aging and IVF treatment outcomes. Advanced maternal age is a known risk factor for miscarriage, accounting largely due to g…

other 2018
Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis
Human Reproduction ·doi:10.1093/humrep/dey241

STUDY QUESTION: Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)? STUDY ANSWER: We identified aberrant gene expression signatures associated with malignant transformation in a…