Eiji Kobayashi

Malignant transformation of adenomyosis is rare, with endometrioid carcinoma being the most common histological type. Herein, we report the first extremely aggressive case of undifferentiated carcinoma arising from adenomyosis. A 59-year-ol…

AIM: To investigate the mechanisms of histone deacetylase (HDAC) 10 inhibitors (HDAC10Is) action in endometriosis and the target molecules of HDAC10Is. METHODS: We assessed the effects of HDAC10Is, tucidinostat and TH34, on the proliferati…

BACKGROUND: Digital approaches to preconception care (PCC) may help increase reproductive health awareness among women of reproductive age. This pilot study evaluated the usability, acceptability, and perceived impact of a digital PCC tool …

BACKGROUND: This study aimed to describe the clinical characteristics of patients with obstructed hemivagina and ipsilateral renal anomaly (OHVIRA)/Herlyn-Werner-Wunderlich (HWW) syndrome and to evaluate the efficacy of minimally invasive m…

Objective: The microRNA hsa-miR-132-5p is upregulated in endometriotic cyst stromal cells (ECSCs). We investigate how hsa-miR-132-5p affects the progression of endometriosis. Methods: Normal endometrial stromal cells (NESCs) that have been …

Ovarian hemorrhage during antithrombotic therapy is sometimes difficult to manage. A 38-year-old woman, diagnosed with Marfan syndrome and implanted with a left ventricular assist device (LVAD) and taking aspirin and warfarin potassium, had…

Endometrioid adenocarcinoma of the uterine cervix is rare and difficult to distinguish from endometrial adenocarcinoma, particularly in large bulky cases. Herein, we report a rare case of a large endometrioid adenocarcinoma in a 58-year-old…

BACKGROUND: This study assesses the feasibility of minimally invasive surgery (MIS) for well-selected epithelial ovarian cancer (EOC) patients. METHODS: We performed a review of data prospectively collected from a single center from 2017 t…

BACKGROUND: Preoperative anemia affects perioperative outcomes and often causes fatigue and psychological disorders. Therefore, anemia should be treated before a patient undergoes surgery. Ninjin'yoeito (NYT), a Japanese Kampo medicine comp…

To assess the effect of dienogest on recurrence of ovarian endometriomas and severity of pain after laparoscopic surgery, a retrospective study of 81 patients was performed at three institutions in Osaka, Japan. Patients had a six-month min…

Advances in surgical and medical treatments for ovarian cancer have improved prognoses. Platinum drugs in particular are pivotal for the medical treatment of ovarian cancer. However, previous studies have revealed that some histological sub…

INTRODUCTION: Total laparoscopic hysterectomy has been reported as having a higher incidence of vaginal cuff dehiscence compared with the abdominal and/or vaginal hysterectomy. The cause of vaginal cuff dehiscence after total laparoscopic h…

Objective: To determine the risk factors which influence the recurrence of endometriomas after laparotomy or laparoscopic surgery.Design: Between 2000 and 2007, 98 patients who had endometrial cysts were treated by laparotomy or laparoscopi…