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The vitamin D receptor (VDR) and aryl hydrocarbon receptor (AHR) are two nuclear receptors that exert their effects by binding with ligands and forming a molecular complex. These complexes translocate to the nucleus and activate the express…
Among prostaglandins, Prostaglandin E2 (PGE2) (PGE2) is considered especially important for decidualization, ovulation, implantation and pregnancy. Four major PGE2 receptor subtypes, EP1, EP2, EP3, EP4, as well as peroxisome proliferator-ac…
Normal pregnancy is a state of hypercoagulability with diminishing fibrinolytic activity, which is mainly caused by an increase of plasminogen activator inhibitor type 1 (PAI-1). PAI-1 is the main inhibitor of plasminogen activators, includ…
Both the implantation and endometriosis are the results of complicated interaction of sex hormones, prostaglandins and cytokines that designate tissue to adhesion, migration and apoptosis. EP1 and EP3 have been implicated to promote these a…
Background: Implantation and endometriosis are the results of intricate interactions of hormones, prostaglandins and cytokines designating tissues to adhesion, migration and apoptosis. EP1 and EP3 have been implicated in promoting these pro…
Background: VDR and AHR are nuclear receptors, which exert their function through binding with ligands and formation of a molecular complex. These complexes translocate to the nucleus and activate the expression of a series of genes with a …