Amjadi F

Among the primary objectives of contemporary assisted reproductive technology research are achieving the births of healthy singletons and improving overall fertility outcomes. Substantial advances have been made in refining the selection of…

OBJECTIVE: While obesity has been associated with poor reproductive outcomes, the specific factors affecting gametes remain unclear. Our primary objective was to assess the relationship between a couple's pre-pregnancy body mass index (BMI)…

This study investigates the proteomic profile of the fallopian tube following exposure to human sperm, with a focus on its role in sperm capacitation, final sperm maturation, successful fertilization, and early embryonic development. Twenty…

OBJECTIVE: Emotional stress leading to cortisol release is an important infertility factor in females. Increased cortisol levels can significantly affect tight junction proteins and dysregulate the implantation process. This study investiga…

OBJECTIVE: This study investigated the metabolic status of the spent culture media from embryos of patients with repeated implantation failure (RIF) undergoing in vitro fertilization-intracytoplasmic sperm injection cycles in comparison wit…

RESEARCH QUESTION: Can time-lapse parameters and the transcriptional profile of cumulus cells be used to achieve a more stringent and non-invasive method of embryo assessment and to identify possible factors affecting the embryo's ability t…

Although the role of myo-inositol (MYO) in promoting the oocyte quality of PCOS patients has been documented in human studies; the cellular effects of this supplement on oocytes have not been directly examined due to ethical limitations. In…

BackgroundEctopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity.ObjectiveWe aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tu…

OBJECTIVE: The DNA integrity of spermatozoa that attach to fallopian tube (FT) cells is higher than spermatozoa that do not attach. FT epithelial cells can distinguish normal and abnormal sperm chromatin. This study investigated the effects…

ObjectiveAlthough intracytoplasmic sperm injection (ICSI) is a way to deal with in vitro fertilization failure, 3% of couples still experience repeated fertilization failure after attempted ICSI, despite having sperm within normal parameter…

ObjectiveRecently, the decellularization technique is introduced as one of the tissue engineering procedures for the treatment of various deficiencies. Here, we aimed to assess the dynamic activity of CCs and HUVECs within decellularized bo…

OBJECTIVES: NOTCH signaling pathway is well known for its role in cell fate, cell survival, cell differentiation, and apoptosis. Some of the NOTCH signaling genes are critical for endometrial function and implantation in animals and appear …

ObjectiveTo determine the localization, expression, and function of Toll-like receptors (TLRs) in fallopian tube epithelial cells.MethodsThe localization of TLRs in fallopian tube epithelial cells was investigated by immunostaining. Surpris…

ObjectiveToll like receptors (TLRs) are one of the main components of the innate im- mune system. It has been reported that expression of these receptors are altered in the female reproductive tract (FRT) during menstrual cycle. Here we use…

BackgroundWomen with polycystic ovary syndrome have lower pregnancy rates, possibly due to the decreased uterine receptivity. Successful implantation depends on protein networks that are essential for cross-talk between the embryo and endom…

BackgroundThe human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We and …

The mucosal immune system in the female reproductive tract (FRT) is well equipped to meet the sexually transmitted pathogens, allogeneic sperm, and the immunologically distinct fetus. Analysis of the FRT indicates that epithelial cells prov…