Ratna Chattopadhyay

BACKGROUND: Adenomyosis and endometriosis are hormone-dependent benign gynecological disorders with overlapping features suggesting that they may share a common origin despite being considered distinct entities. This study compares the expr…

UNLABELLED: Symptomatic adenomyosis is a known impediment to successful implantation and pregnancy in in vitro fertilization; yet optimal pre-treatment strategic approach remains uncertain. This randomized controlled trial compared the effe…

OBJECTIVE: The objective of this study was to investigate the impact of localization of diffuse adenomyosis on reproductive outcomes after frozen embryo transfer (FET). DESIGN: This prospective cohort study was conducted between January 201…

Abstract Study question Can investigating endometriosis—cardiovascular interaction identify women with stage III/IV endometriosis and elucidate pathophysiology of the female heart at a broader level? Summary answer Endothelial dysfunction c…

Abstract Study question Does localization of diffuse adenomyosis impact reproductive outcomes after the frozen embryo transfer (FET)? Summary answer Diffuse adenomyotic lesions involving the junctional zone (JZ) have a greater negative impa…

Abstract Study question Do NOD-like receptor pyrin-containing 3 (NLRP3) signaling affect neutrophil extracellular traps (NET)-osis in women with stage III/IV endometriosis? Summary answer Inflammasome activation whether due to pathogen (dis…

Abstract Study question Do genetic components and functional annotation/s in eutopic endometrium share significant difference to influence diagnosis in adenomyosis? Summary answer An integrated clinico-transcriptomic approach chalk the chie…

Abstract Study question Can metabolic picture of cumulus cell (CC) assess assisted reproductive technology outcome/s in women with adenomyosis/endometriosis and have implications on treatment decisions? Summary answer The differentially exp…

PURPOSE: The study aimed to investigate key intrafollicular prognostic factors among various cytokines and angiogenic molecules for prediction of mature oocytes and good-quality embryos in women with endometriosis undergoing in vitro fertil…

OBJECTIVE: To investigate differences in the activity of matrix metalloproteinases (MMPs) 2 and 9 and their respective tissue inhibitors (TIMPs) in follicular fluid of women with endometriosis, to correlate the findings with IVF outcome, an…

Studies on elevated reactive oxygen species (ROS) levels in granulosa cells (GC) and its subsequent effect on fertilization are limited. Oxidative stress (OS) mediated alterations in GC of infertile women undergoing in vitro fertilization (…

OBJECTIVES: The aim of this study is to examine meiotic spindle in oocytes along with reactive oxygen species (ROS) levels in follicular fluid of women undergoing IVF and to correlate these findings with embryo quality and pregnancy outcome…

Though the role of reactive oxygen species (ROS) in female infertility has been a subject of rigorous research worldwide, there is inadequate information on the cut-off value of ROS in the oocyte microenvironment beyond which ART outcome ma…